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Aashika Sekar

@aashikasekar.bsky.social

129 followers 1.1K following 9 posts

Postdoc interested in studying growth control using Drosophila @taponlab.bsky.social @crick.ac.uk

Aashika Sekar @aashikasekar.bsky.social · 10/07/2026

8/8 We have generated some interesting tools to tease out the role of PP2A regulatory subunits, which we would be happy to share with the Drosophila and PP2A community! Open access here: link.springer.com/article/10.1...

link.springer.com

PP2A phosphatase regulates Hippo signalling in dual manner - The EMBO Journal

Hippo signalling is an evolutionarily conserved pathway that regulates tissue growth. The FERM domain protein Expanded (Ex) integrates polarity cues to activate the Hippo pathway. Previous work has sh...

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Aashika Sekar @aashikasekar.bsky.social · 10/07/2026

7/8 PP2A::Wrd interacts with the upstream Hippo pathway regulator Kibra to protect Ex from degradation.

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Aashika Sekar @aashikasekar.bsky.social · 10/07/2026

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Aashika Sekar @aashikasekar.bsky.social · 10/07/2026

6/8 PP2A can also regulate Ex proteostasis. PP2A::Wrd and PP2A::Tws holoenzymes are involved in proteostatic Ex regulation.

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Aashika Sekar @aashikasekar.bsky.social · 10/07/2026

5/8 And by stabilising Ex, PP2A::Wrd increases Hippo pathway activity.

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Aashika Sekar @aashikasekar.bsky.social · 10/07/2026

4/8 The PP2A::Wrd holoenzyme antagonises Crb-mediated degradation of Ex.

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Aashika Sekar @aashikasekar.bsky.social · 10/07/2026

3/8 PP2A stabilises Ex independently of the STRIPAK complex, which was shown to inhibit Hippo pathway activity.

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Aashika Sekar @aashikasekar.bsky.social · 10/07/2026

2/8 Crumbs (Crb) can inhibit the Hippo pathway by promoting degradation of the upstream Hippo component, Expanded (Ex). We show that Mts, the PP2A catalytic subunit, can antagonise Crb-mediated degradation of Ex.

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Aashika Sekar @aashikasekar.bsky.social · 10/07/2026

1/8 🎉 Super excited to share my work with Paulo Ribeiro at @qmbci.bsky.social- now published @embojournal.org ! We show PP2A can activate the Hippo pathway in Drosophila, in addition to its role as a Hippo negative regulator as part of the STRIPAK complex. 🧵A short thread on what we found below!

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