iiinova — where your digital self keeps evolving

Reposted by Ali Abdul-Sater

Samar Moussa @samarmoussa.bsky.social · 29/05/2026

Excited to share our new study in Environment International showing that tire chemicals transform in the atmosphere into complex mixtures that trigger inflammation in human immune cells. Grateful to co-leads @jliggio.bsky.social @aabdulsater.bsky.social!! www.sciencedirect.com/science/arti...

sciencedirect.com

Atmospheric aging of tire rubber antioxidants forms complex mixtures that trigger inflammation in human macrophages

Antioxidants added to tires to prevent degradation have recently been recognized as emerging environmental contaminants. While their acute aquatic tox…

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Ali Abdul-Sater @aabdulsater.bsky.social · 12/02/2025

We are hiring: ASSISTANT RESEARCH SCIENTIST AT THE PSA CARE HUB AT YORK UNIVERSITY

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Ali Abdul-Sater @aabdulsater.bsky.social · 12/02/2025

We are hiring: ASSOCIATE RESEARCH SCIENTIST AT THE PSA CARE HUB AT YORK UNIVERSITY

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Ali Abdul-Sater @aabdulsater.bsky.social · 12/02/2025

📢 Help us spread the word! Like, share, and tag potential candidates who may be interested in joining the PsA CARE Hub. Together, we can drive innovation and improve outcomes for people living with PsA.

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Ali Abdul-Sater @aabdulsater.bsky.social · 12/02/2025

🔍 We're Hiring! We will soon be recruiting Associate and Assistant Research Scientists to join this groundbreaking initiative. If you're a scientist passionate about inflammation, immunology, or any field that can be applied to PsA research, stay tuned for opportunities!

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Ali Abdul-Sater @aabdulsater.bsky.social · 12/02/2025

focused on unraveling the cellular and molecular mechanisms driving PsA. By providing mentorship, cutting-edge resources, and a collaborative research environment, the Hub will empower the next generation of researchers to establish independent programs dedicated to PsA discovery.

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Ali Abdul-Sater @aabdulsater.bsky.social · 12/02/2025

PsA remains an underexplored disease at the mechanistic level, limiting the development of innovative treatments. The PsA CARE Hub, based at @YorkUniversity and funded by the @KrembilF, will address this critical gap by recruiting and supporting early-career scientists

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Ali Abdul-Sater @aabdulsater.bsky.social · 12/02/2025

🚨 Exciting Announcement! We are thrilled to launch the Psoriatic Arthritis Collaborative and Applied Research Excellence (PsA CARE) Hub, the first research initiative in Canada dedicated to advancing the basic science of psoriatic arthritis (PsA).

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Ali Abdul-Sater @aabdulsater.bsky.social · 05/02/2025

Curious about the details? Check out the full paper here: www.sciencedirect.com/science/arti... Big shoutout to our amazing team and BIG thanks to the funding agencies that supported this work! CIHR, Arthritis Society of Canada and Banting Research Foundation

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Ali Abdul-Sater @aabdulsater.bsky.social · 05/02/2025

Next steps? Targeting TRAF1/cIAP2 interaction with small molecules or biologics! Could this be the next generation of RA therapy? Let’s find out.

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Ali Abdul-Sater @aabdulsater.bsky.social · 05/02/2025

Unlike current RA therapies that block cytokines, our approach prevents inflammation at its source—without broad immune suppression. This could help patients who don’t respond to existing treatments!

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Ali Abdul-Sater @aabdulsater.bsky.social · 05/02/2025

✅ Protected against LPS-induced septic shock ✅ Significantly reduced joint inflammation & disease severity in an RA model This suggests that disrupting TRAF1/cIAP2 signaling lowers inflammation without shutting down immunity!

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Ali Abdul-Sater @aabdulsater.bsky.social · 05/02/2025

🟩 The V203A mutation blocks TRAF1’s interaction with cIAP2. 🟩This shuts down TRAF1’s ability to amplify TLR4-driven inflammation. 🟩As a result, inflammatory cytokine production is significantly reduced.

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Ali Abdul-Sater @aabdulsater.bsky.social · 05/02/2025

We asked: Can we selectively disrupt TRAF1’s inflammatory function while keeping its protective role intact? Using CRISPR gene editing, we identified a mutation (V203A in humans, V196A in mice) that does just that!

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Ali Abdul-Sater @aabdulsater.bsky.social · 05/02/2025

TRAF1 is an immune signaling adapter linked to RA risk. It has a paradoxical role: it can both promote and suppress NF-κB & MAPK signaling. This complexity has made it hard to target therapeutically.

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Ali Abdul-Sater @aabdulsater.bsky.social · 05/02/2025

#RA is an autoimmune disease where chronic inflammation leads to joint damage. Current treatments target inflammatory cytokines, but many patients don’t respond or develop resistance. We need new approaches!

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Ali Abdul-Sater @aabdulsater.bsky.social · 05/02/2025

Excited to share our latest study on #RheumatoidArthritis (RA) in Journal of Autoimmunity! We identified a critical mutation in TRAF1 that selectively reduces inflammation—offering a promising new therapeutic strategy. www.sciencedirect.com/science/arti...

sciencedirect.com

Selective disruption of Traf1/cIAP2 interaction attenuates inflammatory responses and rheumatoid arthritis

Tumor necrosis factor receptor-associated factor 1 (TRAF1) is an immune signaling adapter protein linked to increased susceptibility to rheumatoid art…

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Reposted by Ali Abdul-Sater

Paola A. Marignani @pmarignani.bsky.social · 29/12/2024

Please share with your network. We are migrating Canadian Women in STEM to Bluesky from the other site. Our new website is up and running. Please Join and follow @cdnwomenstem.bsky.social

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Ali Abdul-Sater @aabdulsater.bsky.social · 25/12/2024

Happy holidays from the Abdul-Sater lab ♥️♥️

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Ali Abdul-Sater @aabdulsater.bsky.social · 08/12/2024

"reviewer 1" had a page and a half of comments 🙂

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Ali Abdul-Sater @aabdulsater.bsky.social · 08/12/2024

I don't know why "Reviewer 2" gets a bad rap. We got the reviews back on a new submission and here's Rev 2's comments: "Reviewer #2: The results are persuasive, and the argument is straightforward. I did not find any major problems."

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Ali Abdul-Sater @aabdulsater.bsky.social · 01/12/2024

Would be nice if made available on zoom 🙂

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Reposted by Ali Abdul-Sater

Dr. Dawn Bowdish @msmacrophage.bsky.social · 22/11/2024

I spoke to the CBC Radio about a large measles outbreak in New Brunswick - article link below. I cannot stress enough how serious an infection measles is - recycling an op-ed I wrote on the topic(see link on my webpage for explainer video). www.cbc.ca/news/canada/... www.bowdish.ca/lab/2024/03/...

Image of a Globe & Mail op-ed on measles. For an accessible read see http://www.bowdish.ca/lab/2024/03/07/measles-is-not-a-harmless-childhood-infection-dr-bowdish-explains/

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Ali Abdul-Sater @aabdulsater.bsky.social · 22/11/2024

Here are my first impressions after using this platform for a few days: Bluesky is like Twitter if it went on a detox—no hate, no fake news, just good vibes and civilized conversations 😀

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