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Chemical Science @chemicalscience.rsc.org · 1h

This article is part of our themed collection in celebration of the 130th anniversary of Xi’an Jiaotong University in 2026. You can read that collection here: pubs.rsc.org/sc/coll...

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Chemical Science @chemicalscience.rsc.org · 1h

↗️Trending in Chemical Science↗️ "Photoredox-catalyzed direct formylation of alkenes to access α,β-unsaturated aldehydes" by Le Liu and colleagues. 💡Broad alkene scope with late-stage aldehyde installation under visible light.💡 Read for free: doi.org/10.1039/d6sc...

Graphical abstract showing a visible-light photoredox strategy for the direct β-formylation of alkenes. A general alkene reacts with an α-chloro-N-methoxyphthalimide reagent under blue-light irradiation and a photocatalyst to generate a formyl radical, which is incorporated into the alkene to produce an α,β-unsaturated aldehyde. The method is demonstrated across more than 41 examples, delivering yields of up to 74% and E/Z selectivities of up to 95:5. Representative products include aromatic, fluorinated, highly substituted, and cyclic aldehydes. The figure highlights key challenges such as competing hydrogen atom transfer (HAT) processes and chemo- and regioselectivity, while emphasizing the advantages of easily available substrates, mild reaction conditions, broad substrate scope, and a photoredox-driven process.

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Chemical Science @chemicalscience.rsc.org · 03/10/2026

Trending in Chemical Science! 📈 "Efficient visualization of chemical space" by Akash Surendran, Ramón Alain Miranda-Quintana and colleagues! 👉 Tanimoto-guided PCA maps chemical space faster and better than non-linear methods. Read for free: 🔗 doi.org/10.1039/d6sc...

Infographic showing the N-Ary Mapping Interface (NAMI) workflow for visualizing chemical space. On the left, a binary fingerprint matrix of 0s and 1s represents molecular data. An arrow points to a central panel containing coloured clusters of circles of different sizes, labelled “Global cluster centroid projections,” illustrating grouped regions of chemical space. A magnifying glass highlights one cluster, and a second arrow points to the right-hand panel, where individual molecular structures are displayed within a circle labelled “Local chemical space visualization.” The figure illustrates how NAMI identifies clusters from molecular fingerprints and enables detailed exploration of specific regions of large chemical datasets.

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Chemical Science @chemicalscience.rsc.org · 02/10/2026

Issue 37 is here! #ChemSciCovers Our front cover this week features 'The advent of molecular nanocarbon biology' by Kenichiro Itami, Kazuma Amaike et al. 🤩 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 02/10/2026

Have you seen this new 🔥HOT🔥 article in Chemical Science? "Universal charge-tag labelling of undetectable polymers for mass spectrometric characterization" by Jeremy E. Wulff, J. Scott McIndoe and colleagues. Read for free: 🔗 doi.org/10.1039/D6SC...

Schematic illustration of a polymer functionalized with a mass spectrometry (MS) charge tag. A blue wavy line at the top represents a polymer chain attached to a molecular structure. The molecule contains a trifluoromethyl-substituted aromatic group labeled in red as “charge-tagged hydrocarbon for MS detection,” connected through ether linkages to a triazole ring highlighted in green and labeled “robust linkage.” The triazole is linked to a phosphonium charge tag, highlighted in blue, with a PF₆⁻ counterion. Coloured boxes emphasize the triazole linkage and the phosphonium charge tag, illustrating the design of a permanently charged polymer end group for enhanced MS detection.

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Reposted by Chemical Science

Chemistry World @chemistryworld.com · 02/10/2026

Chemistry World will be covering the chemistry Nobel prize live as it happens from 8am BST on Wednesday 7 October. Ahead of the announcement, we unpack what we know so far about how the Nobel prize winners are chosen. Read here: #ChemSky www.chemistryworld.com/how-are-the-...

chemistryworld.com

How are the winners of the Nobel prizes chosen?

Despite being one of science's most prestigious prizes, the process of awarding the prize is shrouded in mystery

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Chemical Science @chemicalscience.rsc.org · 02/10/2026

Issue 37 of Chemical Science is here! #ChemSciCovers Our front cover this week features work by Kazuma Amaike, Ayaka Ueda and Kenichiro Itami and highlights their Perspective article on 'The advent of molecular nanocarbon biology'! You can read that paper here: doi.org/10.1039/d6sc...

Cover artwork for Chemical Science (Volume 17, Number 37, 30 September 2026). Against a dark, starry background, four white molecular nanocarbon cage and ring structures float in the foreground. In the upper right, a series of elevated black hexagonal platforms display images representing biological systems and applications, including plant roots, a mouse, a membrane-associated protein complex, cellular structures, and a DNA double helix connecting the platforms. The composition illustrates the intersection of nanocarbon chemistry and biology. Cover text includes the Perspective article title, “The advent of molecular nanocarbon biology,” by Kazuma Amaike, Kenichiro Itami and co-workers, alongside Royal Society of Chemistry branding.

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Chemical Science @chemicalscience.rsc.org · 01/10/2026

This article is also part of our collection on organofluorine chemistry, dedicated to Professor David O'Hagan of the University of St Andrews on the occasion of his retirement. Explore that collection here: blogs.rsc.org/sc/202...

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Chemical Science @chemicalscience.rsc.org · 01/10/2026

New and HOT in Chemical Science! 🔥 "Inhibitor fluorination pattern modulates protein surface dynamics and chemically induced dimerization" by Ute A. Hellmich and colleagues. Read for free: doi.org/10.1039/d6sc...

Schematic illustration of a molecular glue strategy targeting the Trypanosoma brucei redox protein Tpx. At the top, a trypanosome parasite is linked to a zoomed-in view of the Tpx redox cascade and a small-molecule glue structure. Three panels compare ligand-binding poses within a Tpx pocket containing a tryptophan (Trp) residue. Left: a detached ligand pose (green) fails to engage Trp, producing a weak molecular glue effect and low Tpx dimer affinity. Centre: a dynamic ligand pose (gold) shows transient interactions and intermediate glue strength. Right: an attached ligand pose (purple) forms stable interactions with Trp, generating a strong molecular glue effect and high Tpx dimer affinity. An arrow along the bottom indicates increasing chemically induced Tpx dimer affinity from left to right.

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Chemical Science @chemicalscience.rsc.org · 30/09/2026

🔥 New and HOT in Chemical Science !🔥 "The peripheral environment: key to advanced single-atom catalysis for CO2 reduction" by Sen Lin, Jian Lin et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 29/09/2026

🔥 New and HOT in Chemical Science !🔥 "Photoredox-catalyzed direct formylation of alkenes to access α,β-unsaturated aldehydes" by Le Liu et al. from Xi'an Jiaotong University, China. Read it for free here: doi.org/10.1039/d6sc...

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Reposted by Chemical Science

Boron Chemistry @boron-chemistry.bsky.social · 22/09/2026

Borane-assisted hydride addition and dihydrogen reductive elimination at iridium: a gateway to Ir(–i)/Ir(i) redox catalysis ( @chemicalscience.rsc.org ): pubs.rsc.org/sc/article/1... ( @lbpblab.bsky.social ) .

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Chemical Science @chemicalscience.rsc.org · 27/09/2026

📢 NEW #ChemSciCovers 'Ion-pairing-modulated magnetic properties of thiaporphyrin CuII complex cations' by Hiromitsu Maeda et al. 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 26/09/2026

Don't miss Hiromitsu Maeda, Yoichi Kobayashi, Gaku Fukuhara et al.'s recent article: #ChemSciCovers 'Anion-controlled ion pairing and assembly of π-electronic cations with orthogonal π-systems' 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 25/09/2026

Issue 36 is here! #ChemSciCovers Our front cover this week features 'Genomic signatures highlight stress-response evasion and translational tuning as key drivers of Escherichia coli adaptation to fluorinated tryptophans' by Nediljko Budisa, Beate Koksch et al. 🤩 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 25/09/2026

📈 Trending in Chemical Science! “Cucurbit[7]uril as a universal anchor for photoswitchable monolayers on gold” by Jiří Kaleta et al. from @iocbprague.bsky.social Read it for free (and check out the cover artwork for this work) here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 24/09/2026

🔥 New and HOT in Chemical Science !🔥 "π-Stacked supramolecular contact ion pairs prohibit quenching and provide control of symmetry in fluorescent dyes" by Bo W. Laursen, Amar H. Flood et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 23/09/2026

📈 Trending in Chemical Science! “Effects of heteroatom doping on hydrogen uptake in tungsten oxide” by Veronica Augustyn et al. from North Carolina State University. Read it for free here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 23/09/2026

🔥 New and HOT in Chemical Science !🔥 "Atomically thin vanadium oxide nanosheets via top-down exfoliation for ultrafast-charging zinc-ion batteries" by Weishen Yang, Kaiyue Zhu et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 23/09/2026

This week's Chemical Science Pick of the Week is "Deep learning of tautomer stability from crystallographic proton positions” by Yingkai Zhang et al. from New York University! Read it for free here: doi.org/10.1039/d6sc... #ChemSciPicks

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Chemical Science @chemicalscience.rsc.org · 22/09/2026

📈 Trending in Chemical Science! “Controlled intra- and extracellular localization of bioorthogonal polymeric nanozymes” by Vincent Rotello et al. from University of Massachusetts. Read it for free here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 22/09/2026

🔥 New and HOT in Chemical Science !🔥 "Heteroleptic Cr4+ molecular color center candidates" by Danna E. Freedman, David D. Awschalom, Timothy C. Berkelbach et al. Read it for free here: doi.org/10.1039/d6sc...

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Reposted by Chemical Science

Eduardo Garcia-Padilla @garciapadilla.bsky.social · 22/09/2026

Check out our latest publication with @guanqichem.bsky.social, now on @chemicalscience.rsc.org❗️The way a reaction rate changes with reaction energy can inform us of its synchronicity. Have a read! doi.org/10.1039/d6sc... #PhysicalOrganicChemistry #ComputationalChemistry

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Chemical Science @chemicalscience.rsc.org · 21/09/2026

📈 Trending in Chemical Science! "Phenothiazine-based TADF emitters with dual conformations for single-molecule white OLEDs" by Anakuthil Anoop, K. N. Narayanan Unni and Joshy Joseph et al. Read it for free here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 20/09/2026

📢 NEW #ChemSciCovers 'PFAS removal by ultra-low loads of a metal–organic cage' by Edmundo G. Percástegui, Raúl Hernández Sánchez et al. 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 19/09/2026

Don't miss Yukatsu Shichibu, Katsuaki Konishi et al.'s recent article: #ChemSciCovers 'N-coordination-driven anchoring of M2 dimers (M = Cu, Ag) on Au6 cluster: structural evolution and enhanced photoluminescence' 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 19/09/2026

📢 NEW #ChemSciCovers 'Beyond a single structure: complementary IR and NMR signatures of multi-minima noncovalent binding' by Pavel Hobza, Štěpán Kment, Martin Dračínský et al. 🔗 doi.org/10.1039/d6sc...

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Reposted by Chemical Science

Royal Society of Chemistry @rsc.org · 18/09/2026

Help shape the future of photothermal materials research. Join scientists worldwide at the Challenges and Solutions for Photothermal Materials & Applications Faraday Discussion. Engage with experts, challenge ideas & contribute to the discussion: rsc.li/photothermal-fd2027 #FD_Photothermal #ChemSky

Faraday Discussions - Challenges and solutions for photothermal materials and applications, 15-17 September 2027 in London, UK. Save the Date

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Chemical Science @chemicalscience.rsc.org · 18/09/2026

📈 Trending in Chemical Science! "Al(II) transfer harnessing a well-defined cadmium precursor" by Dominic Herle, Frerik Wurm, Crispin Lichtenberg and Fabian Dankert Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 18/09/2026

Issue 35 is here! #ChemSciCovers Our front cover this week features 'Borane-assisted hydride addition and dihydrogen reductive elimination at iridium: a gateway to Ir(–i)/Ir(i) redox catalysis' by Hajime Kameo, Didier Bourissou et al. 🤩 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 18/09/2026

🔥 New and HOT in Chemical Science !🔥 "Counterion modulation of aza-BODIPY aggregation behaviour for boosted sonodynamic therapy" by Yao Sun, Sheng Qiu, Jun Li, Junrong Li et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 18/09/2026

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Reposted by Chemical Science

Bach Lab | TUM @bach-lab.bsky.social · 17/09/2026

New paper out in Chemical Science! @chemicalscience.rsc.org 🧪💡 Photochemical deracemization of α-chiral carboxamides, mediated by inter- and intramolecular hydrogen bonding. Great work by Maxi and Biki @bikig6.bsky.social 👏 Check it out: lnkd.in/eDTucuMq #OrgChem #Photochemistry #Deracemization

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Chemical Science @chemicalscience.rsc.org · 17/09/2026

🔥 New and HOT in Chemical Science !🔥 "Synthesis of rare-earth borolide sandwich complexes by multi-electron borole reduction" by Richard A. Layfield, Ming-Liang Tong, Fu-Sheng Guo et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 17/09/2026

📈 Trending in Chemical Science! "Liquid–liquid phase separation of peptides: a molecular foundation for next-generation biomaterials" by Liheng Lu and Huaimin Wang from Westlake University, China. Read this Perspective article for free here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 16/09/2026

NEW in Chemical Science! “A resource-efficient structure-based workflow for fragment progression enables parallel hit discovery and validation of functionally diverse modulators of NCS-1 protein–protein interactions” by Frank von Delft, María José Sánchez-Barrena et al. See doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 16/09/2026

🔥 New and HOT in Chemical Science !🔥 "Metal–oxygen covalency engineering activates stable lattice oxygen in NiCo2O4 spinel for efficient oxygen evolution" by Zhao-Qing Liu, Xiao-Tong Wang et al. from Guangzhou University, China. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 16/09/2026

This week's Chemical Science Pick of the Week is "Nano-heterostructures of topological insulators and soft metallo-supramolecular polymer for solar fuel production” by Kanishka Biswas, Tapas Kumar Maji et al. Read it for free here: doi.org/10.1039/d6sc... #ChemSciPicks

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Reposted by Chemical Science

Marcus Drover @marcuswdrover.bsky.social · 15/09/2026

🚀 🚨 Our latest work on {Ni,Al} heterometallics is now out in Chemical Science Journal. Congrats to the authors esp. Anbang! Another great collaborative effort w/ @crimmingroup.bsky.social 🔗 pubs.rsc.org/sc/article/d...

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Chemical Science @chemicalscience.rsc.org · 15/09/2026

🔥 New and HOT in Chemical Science !🔥 "Surfactant incorporation enhancing the two-electron transfer reaction of MnO2 cathode materials in aqueous Zn batteries" by Xiaoqi Sun, Xiao-Xia Liu et al. from Northeastern University, Shenyang, China. Read it for free here: doi.org/10.1039/d6sc...

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Reposted by Chemical Science

Royal Society of Chemistry @rsc.org · 14/09/2026

Abstract submissions are now open for Digital chemistry discovery. This Faraday Discussion will bring together researchers to discuss the latest developments in digital chemical discovery Submit your oral abstract by 14 December 2026: rsc.li/digital-fd2027 #ChemSky #FD_Digital

This image is an announcement for a digital chemistry discovery event organized by the Royal Society of Chemistry. It is titled "Faraday Discussions" and is scheduled for 8-10 September 2027 in Edinburgh, UK. A "Save the date" message with an arrow is included at the bottom. A partial view of a circular, patterned scientific illustration is on the right side.

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Reposted by Chemical Science

EES Family journals @ees-journals.rsc.org · 09/09/2026

Join us at the next Royal Society of Chemistry Desktop Seminar: Perovskite solar cell circularity featuring Giulia Grancini (University of Pavia). 📅 23 September 2026 at 9:00 am BST (10:00 am CEST) 🔗 Register now at rsc.zoom.us/webinar/regi... For more information see www.rsc.org/events/find-...

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Reposted by Chemical Science

RSC-CICAG @rsc-cicag.bsky.social · 11/09/2026

Registrations are open from the RSC-CICAG Quantum Computing in Chemistry: Current Capabilities and the Road to Utility taking place on 19th November 2026 👉 t.ly/7Nagb 🚨 Deadline for registration: Monday 9th November 2026 Bursary applications are open too! Watch this space for bursary details.

Registrations are open for the RSC-CICAG Quantum Computing in Chemistry. The event will take place on 19th November 2026. Registrations close on 9th November 2026.

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Chemical Science @chemicalscience.rsc.org · 11/09/2026

🔥 New and HOT in Chemical Science !🔥 "Modular synthesis of functionalized azetidines through visible-light copper-catalyzed carboamination of 1,3-dienes with azabicyclo[1.1.0]butanes" by Sungwoo Hong et al. from KAIST, South Korea. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 11/09/2026

The catalyst displays a hydrogen bonding site which allows for a differentiation between the two enantiomers and operates by a reversible hydrogen atom transfer. It was found that α-alkoxy or α-amino substituents enable an efficient deracemization (up to 99.5 : 0.5 e.r.).

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Chemical Science @chemicalscience.rsc.org · 11/09/2026

In this study, carboxylic acid amides (carboxamides) with a substituent in the α-position were investigated in a photochemical deracemization mediated by a chiral aromatic ketone.

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Chemical Science @chemicalscience.rsc.org · 11/09/2026

This week's Chemical Science Pick of the Week is "Photochemical deracemization of α-chiral carboxamides mediated by inter- and intramolecular hydrogen bonding" by @bach-lab.bsky.social from Technische Universität München. Read it for free here: lnkd.in/eDTucuMq

Schematic overview of a light-driven enantioselective transformation enabled by hydrogen-bond recognition. A chiral photocatalyst (catalyst 1), containing a rigid bicyclic framework and amide groups highlighted by grey boxes, interacts with a racemic aryl-substituted substrate through intramolecular hydrogen bonds (blue and magenta arrows). Under UV light (hν), catalyst 1 promotes divergent reactions depending on the substituent X. For X = OR, the reaction affords an oxindole product with an R-configured stereocentre (blue-highlighted) and up to 99.5:0.5 enantiomeric ratio (e.r.). For X = NHR, the reaction gives the corresponding S-configured product (magenta-highlighted) with up to 96:4 e.r. A note indicates that intermolecular hydrogen bonding is used for molecular recognition. A “Pick of the Week” badge appears in the lower left corner.

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Chemical Science @chemicalscience.rsc.org · 10/09/2026

🔥 New and HOT in Chemical Science !🔥 "Self-assembled polyoxometalate enables efficient and stable proton conduction in high-temperature polymer electrolyte membranes" by Haolong Li et al. from Jilin University, China. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 10/09/2026

Trending in Chemical Science! 📈 "Ligand-enabled palladium-catalyzed late-stage C–H fluorination of arenes" by Debabrata Maiti and colleagues. 👉 Mild Pd-catalyzed, regioselective arene fluorination enables broad late-stage drug modification. Read for free: doi.org/10.1039/d6sc...

Graphical abstract illustrating palladium-catalyzed late-stage C-H fluorination of arenes. An aryl substrate bearing a C-H bond reacts with an electrophilic fluorine source, shown by an arrow leading to a fluorinated aryl product. At the centre, a newly designed pyridone-aminophenyl bidentate ligand coordinates palladium and enables the catalytic process. Key features highlighted below the scheme are: newly engineered bidentate ligand, late-stage fluorination, regioselectivity, fluorouracil synthesis, and broad substrate scope. The graphic uses a light grey background with teal, blue, orange, black, and red accents.

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