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Chemical Science @chemicalscience.rsc.org · 3h

↗️Trending in Chemical Science↗️ "Photoredox-catalyzed direct formylation of alkenes to access α,β-unsaturated aldehydes" by Le Liu and colleagues. 💡Broad alkene scope with late-stage aldehyde installation under visible light.💡 Read for free: doi.org/10.1039/d6sc...

Graphical abstract showing a visible-light photoredox strategy for the direct β-formylation of alkenes. A general alkene reacts with an α-chloro-N-methoxyphthalimide reagent under blue-light irradiation and a photocatalyst to generate a formyl radical, which is incorporated into the alkene to produce an α,β-unsaturated aldehyde. The method is demonstrated across more than 41 examples, delivering yields of up to 74% and E/Z selectivities of up to 95:5. Representative products include aromatic, fluorinated, highly substituted, and cyclic aldehydes. The figure highlights key challenges such as competing hydrogen atom transfer (HAT) processes and chemo- and regioselectivity, while emphasizing the advantages of easily available substrates, mild reaction conditions, broad substrate scope, and a photoredox-driven process.

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Chemical Science @chemicalscience.rsc.org · 03/10/2026

Trending in Chemical Science! 📈 "Efficient visualization of chemical space" by Akash Surendran, Ramón Alain Miranda-Quintana and colleagues! 👉 Tanimoto-guided PCA maps chemical space faster and better than non-linear methods. Read for free: 🔗 doi.org/10.1039/d6sc...

Infographic showing the N-Ary Mapping Interface (NAMI) workflow for visualizing chemical space. On the left, a binary fingerprint matrix of 0s and 1s represents molecular data. An arrow points to a central panel containing coloured clusters of circles of different sizes, labelled “Global cluster centroid projections,” illustrating grouped regions of chemical space. A magnifying glass highlights one cluster, and a second arrow points to the right-hand panel, where individual molecular structures are displayed within a circle labelled “Local chemical space visualization.” The figure illustrates how NAMI identifies clusters from molecular fingerprints and enables detailed exploration of specific regions of large chemical datasets.

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Chemical Science @chemicalscience.rsc.org · 02/10/2026

Issue 37 is here! #ChemSciCovers Our front cover this week features 'The advent of molecular nanocarbon biology' by Kenichiro Itami, Kazuma Amaike et al. 🤩 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 02/10/2026

Have you seen this new 🔥HOT🔥 article in Chemical Science? "Universal charge-tag labelling of undetectable polymers for mass spectrometric characterization" by Jeremy E. Wulff, J. Scott McIndoe and colleagues. Read for free: 🔗 doi.org/10.1039/D6SC...

Schematic illustration of a polymer functionalized with a mass spectrometry (MS) charge tag. A blue wavy line at the top represents a polymer chain attached to a molecular structure. The molecule contains a trifluoromethyl-substituted aromatic group labeled in red as “charge-tagged hydrocarbon for MS detection,” connected through ether linkages to a triazole ring highlighted in green and labeled “robust linkage.” The triazole is linked to a phosphonium charge tag, highlighted in blue, with a PF₆⁻ counterion. Coloured boxes emphasize the triazole linkage and the phosphonium charge tag, illustrating the design of a permanently charged polymer end group for enhanced MS detection.

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Chemical Science @chemicalscience.rsc.org · 02/10/2026

Issue 37 of Chemical Science is here! #ChemSciCovers Our front cover this week features work by Kazuma Amaike, Ayaka Ueda and Kenichiro Itami and highlights their Perspective article on 'The advent of molecular nanocarbon biology'! You can read that paper here: doi.org/10.1039/d6sc...

Cover artwork for Chemical Science (Volume 17, Number 37, 30 September 2026). Against a dark, starry background, four white molecular nanocarbon cage and ring structures float in the foreground. In the upper right, a series of elevated black hexagonal platforms display images representing biological systems and applications, including plant roots, a mouse, a membrane-associated protein complex, cellular structures, and a DNA double helix connecting the platforms. The composition illustrates the intersection of nanocarbon chemistry and biology. Cover text includes the Perspective article title, “The advent of molecular nanocarbon biology,” by Kazuma Amaike, Kenichiro Itami and co-workers, alongside Royal Society of Chemistry branding.

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Chemical Science @chemicalscience.rsc.org · 01/10/2026

New and HOT in Chemical Science! 🔥 "Inhibitor fluorination pattern modulates protein surface dynamics and chemically induced dimerization" by Ute A. Hellmich and colleagues. Read for free: doi.org/10.1039/d6sc...

Schematic illustration of a molecular glue strategy targeting the Trypanosoma brucei redox protein Tpx. At the top, a trypanosome parasite is linked to a zoomed-in view of the Tpx redox cascade and a small-molecule glue structure. Three panels compare ligand-binding poses within a Tpx pocket containing a tryptophan (Trp) residue. Left: a detached ligand pose (green) fails to engage Trp, producing a weak molecular glue effect and low Tpx dimer affinity. Centre: a dynamic ligand pose (gold) shows transient interactions and intermediate glue strength. Right: an attached ligand pose (purple) forms stable interactions with Trp, generating a strong molecular glue effect and high Tpx dimer affinity. An arrow along the bottom indicates increasing chemically induced Tpx dimer affinity from left to right.

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Chemical Science @chemicalscience.rsc.org · 30/09/2026

🔥 New and HOT in Chemical Science !🔥 "The peripheral environment: key to advanced single-atom catalysis for CO2 reduction" by Sen Lin, Jian Lin et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 29/09/2026

🔥 New and HOT in Chemical Science !🔥 "Photoredox-catalyzed direct formylation of alkenes to access α,β-unsaturated aldehydes" by Le Liu et al. from Xi'an Jiaotong University, China. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 27/09/2026

📢 NEW #ChemSciCovers 'Ion-pairing-modulated magnetic properties of thiaporphyrin CuII complex cations' by Hiromitsu Maeda et al. 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 26/09/2026

Don't miss Hiromitsu Maeda, Yoichi Kobayashi, Gaku Fukuhara et al.'s recent article: #ChemSciCovers 'Anion-controlled ion pairing and assembly of π-electronic cations with orthogonal π-systems' 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 25/09/2026

Issue 36 is here! #ChemSciCovers Our front cover this week features 'Genomic signatures highlight stress-response evasion and translational tuning as key drivers of Escherichia coli adaptation to fluorinated tryptophans' by Nediljko Budisa, Beate Koksch et al. 🤩 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 25/09/2026

📈 Trending in Chemical Science! “Cucurbit[7]uril as a universal anchor for photoswitchable monolayers on gold” by Jiří Kaleta et al. from @iocbprague.bsky.social Read it for free (and check out the cover artwork for this work) here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 24/09/2026

🔥 New and HOT in Chemical Science !🔥 "π-Stacked supramolecular contact ion pairs prohibit quenching and provide control of symmetry in fluorescent dyes" by Bo W. Laursen, Amar H. Flood et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 23/09/2026

📈 Trending in Chemical Science! “Effects of heteroatom doping on hydrogen uptake in tungsten oxide” by Veronica Augustyn et al. from North Carolina State University. Read it for free here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 23/09/2026

🔥 New and HOT in Chemical Science !🔥 "Atomically thin vanadium oxide nanosheets via top-down exfoliation for ultrafast-charging zinc-ion batteries" by Weishen Yang, Kaiyue Zhu et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 23/09/2026

This week's Chemical Science Pick of the Week is "Deep learning of tautomer stability from crystallographic proton positions” by Yingkai Zhang et al. from New York University! Read it for free here: doi.org/10.1039/d6sc... #ChemSciPicks

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Chemical Science @chemicalscience.rsc.org · 22/09/2026

📈 Trending in Chemical Science! “Controlled intra- and extracellular localization of bioorthogonal polymeric nanozymes” by Vincent Rotello et al. from University of Massachusetts. Read it for free here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 22/09/2026

🔥 New and HOT in Chemical Science !🔥 "Heteroleptic Cr4+ molecular color center candidates" by Danna E. Freedman, David D. Awschalom, Timothy C. Berkelbach et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 21/09/2026

📈 Trending in Chemical Science! "Phenothiazine-based TADF emitters with dual conformations for single-molecule white OLEDs" by Anakuthil Anoop, K. N. Narayanan Unni and Joshy Joseph et al. Read it for free here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 20/09/2026

📢 NEW #ChemSciCovers 'PFAS removal by ultra-low loads of a metal–organic cage' by Edmundo G. Percástegui, Raúl Hernández Sánchez et al. 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 19/09/2026

Don't miss Yukatsu Shichibu, Katsuaki Konishi et al.'s recent article: #ChemSciCovers 'N-coordination-driven anchoring of M2 dimers (M = Cu, Ag) on Au6 cluster: structural evolution and enhanced photoluminescence' 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 19/09/2026

📢 NEW #ChemSciCovers 'Beyond a single structure: complementary IR and NMR signatures of multi-minima noncovalent binding' by Pavel Hobza, Štěpán Kment, Martin Dračínský et al. 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 18/09/2026

📈 Trending in Chemical Science! "Al(II) transfer harnessing a well-defined cadmium precursor" by Dominic Herle, Frerik Wurm, Crispin Lichtenberg and Fabian Dankert Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 18/09/2026

Issue 35 is here! #ChemSciCovers Our front cover this week features 'Borane-assisted hydride addition and dihydrogen reductive elimination at iridium: a gateway to Ir(–i)/Ir(i) redox catalysis' by Hajime Kameo, Didier Bourissou et al. 🤩 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 18/09/2026

🔥 New and HOT in Chemical Science !🔥 "Counterion modulation of aza-BODIPY aggregation behaviour for boosted sonodynamic therapy" by Yao Sun, Sheng Qiu, Jun Li, Junrong Li et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 17/09/2026

🔥 New and HOT in Chemical Science !🔥 "Synthesis of rare-earth borolide sandwich complexes by multi-electron borole reduction" by Richard A. Layfield, Ming-Liang Tong, Fu-Sheng Guo et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 17/09/2026

📈 Trending in Chemical Science! "Liquid–liquid phase separation of peptides: a molecular foundation for next-generation biomaterials" by Liheng Lu and Huaimin Wang from Westlake University, China. Read this Perspective article for free here: doi.org/10.1039/d5sc...

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Chemical Science @chemicalscience.rsc.org · 16/09/2026

NEW in Chemical Science! “A resource-efficient structure-based workflow for fragment progression enables parallel hit discovery and validation of functionally diverse modulators of NCS-1 protein–protein interactions” by Frank von Delft, María José Sánchez-Barrena et al. See doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 16/09/2026

🔥 New and HOT in Chemical Science !🔥 "Metal–oxygen covalency engineering activates stable lattice oxygen in NiCo2O4 spinel for efficient oxygen evolution" by Zhao-Qing Liu, Xiao-Tong Wang et al. from Guangzhou University, China. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 16/09/2026

This week's Chemical Science Pick of the Week is "Nano-heterostructures of topological insulators and soft metallo-supramolecular polymer for solar fuel production” by Kanishka Biswas, Tapas Kumar Maji et al. Read it for free here: doi.org/10.1039/d6sc... #ChemSciPicks

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Chemical Science @chemicalscience.rsc.org · 15/09/2026

🔥 New and HOT in Chemical Science !🔥 "Surfactant incorporation enhancing the two-electron transfer reaction of MnO2 cathode materials in aqueous Zn batteries" by Xiaoqi Sun, Xiao-Xia Liu et al. from Northeastern University, Shenyang, China. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 11/09/2026

🔥 New and HOT in Chemical Science !🔥 "Modular synthesis of functionalized azetidines through visible-light copper-catalyzed carboamination of 1,3-dienes with azabicyclo[1.1.0]butanes" by Sungwoo Hong et al. from KAIST, South Korea. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 11/09/2026

This week's Chemical Science Pick of the Week is "Photochemical deracemization of α-chiral carboxamides mediated by inter- and intramolecular hydrogen bonding" by @bach-lab.bsky.social from Technische Universität München. Read it for free here: lnkd.in/eDTucuMq

Schematic overview of a light-driven enantioselective transformation enabled by hydrogen-bond recognition. A chiral photocatalyst (catalyst 1), containing a rigid bicyclic framework and amide groups highlighted by grey boxes, interacts with a racemic aryl-substituted substrate through intramolecular hydrogen bonds (blue and magenta arrows). Under UV light (hν), catalyst 1 promotes divergent reactions depending on the substituent X. For X = OR, the reaction affords an oxindole product with an R-configured stereocentre (blue-highlighted) and up to 99.5:0.5 enantiomeric ratio (e.r.). For X = NHR, the reaction gives the corresponding S-configured product (magenta-highlighted) with up to 96:4 e.r. A note indicates that intermolecular hydrogen bonding is used for molecular recognition. A “Pick of the Week” badge appears in the lower left corner.

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Chemical Science @chemicalscience.rsc.org · 10/09/2026

🔥 New and HOT in Chemical Science !🔥 "Self-assembled polyoxometalate enables efficient and stable proton conduction in high-temperature polymer electrolyte membranes" by Haolong Li et al. from Jilin University, China. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 10/09/2026

Trending in Chemical Science! 📈 "Ligand-enabled palladium-catalyzed late-stage C–H fluorination of arenes" by Debabrata Maiti and colleagues. 👉 Mild Pd-catalyzed, regioselective arene fluorination enables broad late-stage drug modification. Read for free: doi.org/10.1039/d6sc...

Graphical abstract illustrating palladium-catalyzed late-stage C-H fluorination of arenes. An aryl substrate bearing a C-H bond reacts with an electrophilic fluorine source, shown by an arrow leading to a fluorinated aryl product. At the centre, a newly designed pyridone-aminophenyl bidentate ligand coordinates palladium and enables the catalytic process. Key features highlighted below the scheme are: newly engineered bidentate ligand, late-stage fluorination, regioselectivity, fluorouracil synthesis, and broad substrate scope. The graphic uses a light grey background with teal, blue, orange, black, and red accents.

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Chemical Science @chemicalscience.rsc.org · 10/09/2026

Beautiful vanadium complexes and their interconversion within! You can read the full paper for free, here: doi.org/10.1039/d6sc...

Figure comparing two vanadium-containing metallacyclic complexes, labelled 1-H and 1-Me. Ball-and-stick crystal structures are shown on the left, with vanadium highlighted in purple, silicon in yellow, nitrogen in blue, carbon in grey, and hydrogen in white. Simplified ring diagrams on the right identify atoms Si₁, Si₂, Cα, Cβ, and Cα′ and list selected bond lengths. For 1-H, V–Cα = 1.886(2) Å, V–Cβ = 2.069(2) Å, and V–Cα′ = 1.888(3) Å. For 1-Me, V–Cα = 1.865(3) Å, V–Cβ = 2.106(3) Å, and V–Cα′ = 1.877(3) Å. The comparison highlights differences in metal-carbon bonding within the five-membered vanadacycle rings.

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Chemical Science @chemicalscience.rsc.org · 09/09/2026

🔥 New and HOT in Chemical Science !🔥 "Simulated transient absorption reveals torsion-dependent nonradiative relaxation in a near-infrared nanographene emitter" by Sebastian Fernandez-Alberti et al. from Universidad Nacional de Quilmes/CONICET, Argentina. Read it for free: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 08/09/2026

🔥 New and HOT in Chemical Science !🔥 "Synergistic effects in s- and d-block heterometallic compounds: small molecule activation and catalysis" by Martin Gawron and Robert Wolf from the University of Regensburg, Germany. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 08/09/2026

📈 Trending in ChemSci! “Core-to-core overlap enables efficient interchain charge transport beyond crystalline domains in a conjugated polymer: high fill factors in thick organic photovoltaic cells” by Tsubasa Mikie, Yusuke Nishiyama, Hideo Ohkita, Itaru Osaka et al. 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 07/09/2026

🔥 New and HOT in Chemical Science !🔥 "Continuous blueshift of self-trapped exciton emission upon compression and decompression in one-dimensional (C4H8N)2PbCl4" by Zewei Quan et al. from Southern University of Science and Technology, China. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 06/09/2026

🔥 New and HOT in Chemical Science !🔥 "In situ visualization of interfacial evolution in Cr-modified zinc anodes via atomic force microscopy" by Chaofeng Zhang, Shulei Chou, and Lin Li et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 05/09/2026

Don't miss Junyu Chen, Zongxiu Nie and Yuze Li et al.'s recent article: #ChemSciCovers 'Field-enhanced graphene fiber arrays reveal serum metabolic alterations in pancreatic cancer' 🔗 doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 05/09/2026

📢 NEW #ChemSciCovers 'Surface co-crystallization with an organic single crystal enables vapochromic and luminescent detection of phenols' by Ivan Bondarenko and Gonzalo Campillo-Alvarado et al. 🔗 doi.org/10.1039/d6sc... Cover art by Ivan Bondarenko. Gonzalo Campillo-Alvarado @reed.edu

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Chemical Science @chemicalscience.rsc.org · 04/09/2026

Issue 34 is here! #ChemSciCovers Our front cover this week features 'High-throughput bead-based cytokine profiling reveals dynamic immune signatures and identifies candidate exploratory biomarkers in CAR-T therapy' by Hongzhe Sun et al. 🤩 🔗 doi.org/10.1039/d6sc... Image generation: Nano Banana

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Chemical Science @chemicalscience.rsc.org · 04/09/2026

🔥 New and HOT in Chemical Science !🔥 "The crystalline radical anion salt of a free N-heterocyclic carbene" by David Martin et al. Univ. Grenoble Alpes, France. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 03/09/2026

📈 Trending in Chemical Science! “Diiron µ2-N2 complexes in bimetallic, four-fold bond activations of SiH4 to produce µ2-silicide complexes” by T. Don Tilley et al. from the University of California, Berkeley, USA. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 03/09/2026

🔥 New and HOT in Chemical Science !🔥 "Radical–carbanion relay enabled by earth-abundant titanium: carboxylation of 1°, 2°, and 3° benzyl chlorides with CO2" by Yajun Jian and Ziwei Gao et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 02/09/2026

Our Chemical Science Pick of the Week for this week is "Modular assembly and property profiling of an expansive, shape-defined library of pentacyclic saturated N-heterocycles" by Wolfgang Haap and Jeffrey W. Bode et al. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 02/09/2026

📈 Trending in Chemical Science! “Trifluoromethylation of Pyridines through Skeletal Rearrangement” by Michael Greaney et al. from the University of Manchester, UK. Read it for free here: doi.org/10.1039/d6sc...

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Chemical Science @chemicalscience.rsc.org · 01/09/2026

🔥 New and HOT in Chemical Science !🔥 "Aggregated-state arylborane-pillar[5]arenes: a new three-in-one method for the modulation of circularly polarized luminescence" by Niu Zhang and Pangkuan Chen et al. from the Beijing Institute of Technology of China. Read it here: doi.org/10.1039/d6sc...

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