1Day Sooner @1daysooner.bsky.social · 02/10/2026Closing the Pregnancy & Lactation Evidence Gap: More than 90% of pregnant people take at least one medication, yet fewer than 10% of drugs approved since 1980 have evidence on pregnancy safety. Three recent conversations show where the gap starts and how to close it. 110
1Day Sooner @1daysooner.bsky.social · 25/09/2026Trials We Love! What's happening? Merck's Phase 3 trial is enrolling young women in Kenya, South Africa, and Uganda to test whether a pill taken just once a month can prevent HIV as well as, or better than, today's daily PrEP. 100
1Day Sooner @1daysooner.bsky.social · 18/09/2026HHS's Office of Inspector General asked whether federal fraud and abuse law is making it harder than it should be to pay clinical trial participants fairly. 111
1Day Sooner @1daysooner.bsky.social · 16/09/2026Registration is live (both for in-person and virtual attendance) for Global Harmonization for Data Access & Exchange. @1daysooner.bsky.social supported the planning of this event, which is being hosted by the Reagan-Udall Foundation for the FDA: reaganudall.org/news-and-eve...reaganudall.orgGlobal Harmonization for Data Access & ExchangeReagan-Udall Foundation for the FDA, independent 501(c)(3) organization created by Congress to advance the mission of the Food and Drug Administration. 100
1Day Sooner @1daysooner.bsky.social · 16/09/2026"The $500,000 grant to 1Day Sooner will help the group prove it can obtain the data troves of bankrupt companies, says the organization’s president and cofounder, Josh Morrison. He thinks nonexclusive copies of company datasets could be acquired for only “a few tens of thousands of dollars” each." 100
1Day Sooner @1daysooner.bsky.social · 15/09/2026Highlights from our September newsletter: ➡️ 1Day Sooner was one of 128 advocacy groups who signed in support of the @americancancersoc.bsky.social Action Network letter urging for the adoption of the Clinical Trial Modernization Act. Read the letter here: www.fightcancer.org/releases/pub...fightcancer.orgPublic Health Organizations Urge HHS to Remove Financial Barriers in Clinical Trial ParticipationToday, the American Cancer Society Cancer Action Network (ACS CAN), joined by 128 other patient advocacy groups, public health organizations and professional societies, submitted a letter responding t... 100
1Day Sooner @1daysooner.bsky.social · 10/09/2026Tabitha Kisakye was a public health student in Uganda when she learned researchers needed healthy volunteers for a schistosomiasis study — people willing to be deliberately infected. She weighed the risks, then enrolled. 100
1Day Sooner @1daysooner.bsky.social · 01/09/2026On August 14, 1Day Sooner and The Malawi Liverpool Wellcome Research Programme (www.mlw.mw) welcomed 50 clinical trial volunteers, research teams, and public officials to Blantyre, Malawi to celebrate healthy volunteers and recognize their contributions to clinical research. 100
1Day Sooner @1daysooner.bsky.social · 10/08/2026Clinical trials are changing—and implementation will matter. On July 2, 1Day Sooner convened a closed-door roundtable with experts from academia, industry, and advocacy to discuss HHS’s Operation TrialBlazer, draft guidance, and pilot initiatives. 100
1Day Sooner @1daysooner.bsky.social · 10/08/2026Trials We Love! What's happening? Researchers are using a carefully controlled dengue human challenge model in healthy adult volunteers to study how the virus interacts with the human immune system. 111
1Day Sooner @1daysooner.bsky.social · 10/08/2026On July 30, 1Day Sooner's Participant Council met for a focus session on participant compensation — what makes it fair and how it should be calculated. The summary notes are now public. A few takeaways 🧵 100
1Day Sooner @1daysooner.bsky.social · 09/08/2026We're excited to share that @coefficientgiving.bsky.social is supporting our clinical trial policy advocacy. Coefficient Giving works with a range of donors who share its commitment to cost-effective, high-impact giving. 110
1Day Sooner @1daysooner.bsky.social · 29/07/2026We can cure hepatitis C, yet it still takes more years of life in Canada than any other infectious disease — and there's still no vaccine. Canada has the researchers, infrastructure, and volunteers to make one. Our latest in @healthydebate.bsky.social Read more: healthydebate.ca/2026/07/topi... 000
1Day Sooner @1daysooner.bsky.social · 28/07/2026Next in our Meet the Team series: Zacharia Kafuko. Before leading 1Day Africa Zach was a biochemist in Seychelles. Early in the pandemic he read a BBC article calling for human challenge trial volunteers and that set him on the path to 1Day Sooner. 100
Reposted by 1Day SoonerNIHR Biomedical Research Centre: Oxford @oxfordbrc.bsky.social · 28/07/2026It’s #WorldHepatitisDay, and recruitment has begun in a ground-breaking study that will see participants infected with the #hepatitis C virus (and treated) – as an important first step on the road to future testing of vaccine candidates against the disease oxfordbrc.nihr.ac.uk/recruitment-... 1/2 232
1Day Sooner @1daysooner.bsky.social · 28/07/2026Marcus Dahl has volunteered for two challenge trials at Oxford — deliberately exposed to COVID-19, then a new TB vaccine — so researchers could learn how to fight both. 101
1Day Sooner @1daysooner.bsky.social · 16/07/20261Day Sooner and 1Day Africa commend the University of Oxford on this major step taken by the UK in the fight against Ebola! www.bbc.com/news/article...bbc.comUK starts first vaccine trial, eight weeks into Ebola emergencyThe UK medicines regulator has given approval for an experimental vaccine to be tested on healthy adults. 130
1Day Sooner @1daysooner.bsky.social · 14/07/20261Day Sooner joins nearly 200 orgs behind the Clinical Trial Modernization Act (S. 4440). The right to take part in research shouldn't depend on your income or your zip code. This bill clears the cost and distance barriers that keep willing participants out. #ClinicalTrials 010
1Day Sooner @1daysooner.bsky.social · 10/07/2026Controlled human infection (CHI) trials deliberately expose healthy volunteers to a pathogen. After surveying 70 CHI and 98 phase I participants to see what drives them, this study found that CHI volunteers are motivated more by altruism than by reimbursement. 100
1Day Sooner @1daysooner.bsky.social · 25/06/2026Nearly 50M people live with hepatitis C globally, with ~1M new infections each year. Oxford's HIT Study is a major step toward an HCV human challenge model that could help test vaccines faster—and move us closer to elimination. Learn more here: communities.springernature.com/posts/the-hi...communities.springernature.comThe HIT Study: towards a Hepatitis C controlled human infection model (ISRCTN12181449) 100
Reposted by 1Day SoonerAmerican Cancer Society Cancer Action Network @acscan.bsky.social · 18/06/2026Clinical trials can save lives from cancer. But not everyone can access them. Congress has an opportunity to change this with a new bill. Help us spread the word so more people understand why #ClinicalTrials matter and why we need Congress to pass this legislation. 01520
1Day Sooner @1daysooner.bsky.social · 11/06/2026Meet Elizabeth Rouha. She volunteered for a first-of-its-kind C. difficile challenge study in Leiden — and walked away with something she didn't expect: a sense that research participation can be collaborative, even empowering, rather than intimidating. 110
1Day Sooner @1daysooner.bsky.social · 11/06/20261Day Sooner is joining an Amsterdam UMC project that aims to chart a responsible path—with participants at the table from day one—toward a Lyme disease human challenge model. Press release: www.1daysooner.org/press-releas... 000
1Day Sooner @1daysooner.bsky.social · 11/06/2026Our latest newsletter is out — featuring participant stories, policy updates, staff highlights, and a new opportunity to join the 1Day Sooner team. A few highlights below: 100
1Day Sooner @1daysooner.bsky.social · 11/06/2026Trials We Love! What’s happening? Researchers tested an investigational EBV vaccine in healthy adult volunteers for the first time, finding it was generally well tolerated and triggered strong immune responses. 100
1Day Sooner @1daysooner.bsky.social · 09/06/2026Thanks to @founderspledge.com for generously supporting this work! Learn more here: www.founderspledge.com/programs/ghd... 000
1Day Sooner @1daysooner.bsky.social · 09/06/2026Strep A kills ~500,000 people a year, and a vaccine is within reach—candidates have cleared Phase 1 with no serious safety signals. We were glad to see @coefficientgiving.bsky.social announce the Strep A Vaccine Fund (coefficientgiving.org/research/ann...) 110
1Day Sooner @1daysooner.bsky.social · 01/06/2026It's time for more Trials We Love! What's happening? A clinical trial in Melbourne is testing an mRNA vaccine designed to help the immune system fight Epstein–Barr virus (EBV), a virus that infects over 90% of adults worldwide. 100
1Day Sooner @1daysooner.bsky.social · 21/05/2026Americans spend 90% of their time indoors, breathing air that's often dirtier than what's outside. The hidden cost? Asthma, COPD, heart disease, and costly outbreaks of disease. 100
1Day Sooner @1daysooner.bsky.social · 20/05/20261Day Sooner is a nonprofit that advocates for healthy volunteers in high-impact clinical trials and today we recognize the researchers and participants who make trials possible! #ClinicalTrialsDay #CTD2026 001
1Day Sooner @1daysooner.bsky.social · 20/05/2026What’s happening? A clinical trial tested a vaccine designed to prevent illness from Epstein-Barr virus, the common virus best known for causing mono. 100
1Day Sooner @1daysooner.bsky.social · 12/05/2026Meet Roopesh! He’s one of the remarkable team of volunteers who make up 1Day Sooner’s Participant Council. You can read his full profile on our website to learn more about how trial participation shaped his advocacy commitments! 100
1Day Sooner @1daysooner.bsky.social · 07/05/2026We're launching a series introducing the members of our team and the incredible work they do at 1Day Sooner! First up is Paul Zimmer-Harwood, Research Lead for Clinical Trials, whose focus has been on Hepatitis C vaccine development. 100
1Day Sooner @1daysooner.bsky.social · 05/05/2026Trials we love! What’s happening? NIH is recruiting healthy adults ages 18–29 for a Phase 1 study testing two Epstein-Barr virus vaccine candidates. 100
1Day Sooner @1daysooner.bsky.social · 30/04/20261Day Africa signed onto a declaration to improve pandemic preparedness across Africa called the “Nairobi Declaration on African Health Security and Collaborative Disease Surveillance.” 100
1Day Sooner @1daysooner.bsky.social · 29/04/2026@bsky.app 1Day Sooner's Participant Council brings together research volunteers from around the world together to share advice, lived experience, and perspectives on trial participation. 100
1Day Sooner @1daysooner.bsky.social · 21/04/2026What’s happening? A challenge trial in Kenya tested malaria vaccines and showed that route of infection matters. Vaccines targeting the circumsporozoite protein protected volunteers when parasites entered through the skin, but not when injected straight into the bloodstream. 100
1Day Sooner @1daysooner.bsky.social · 15/04/2026What’s Happening: This study looks at how psilocybin, along with a participant’s mindset and environment, affects the psychedelic experience and mental well-being. Volunteers receive either psilocybin or a placebo in different conditions. 100
1Day Sooner @1daysooner.bsky.social · 09/04/2026This is the first in a series spotlighting the volunteers who make up 1Day Sooner's Participant Council: Meet Angelique Mseteka! Angelique first participated in a clinical trial to serve her community, and now she's passionate about helping others to do the same! 100
1Day Sooner @1daysooner.bsky.social · 07/04/2026What’s happening: Researchers tested a first-in-human mRNA vaccine for Nipah virus and found it was safe and triggered strong immune responses in healthy adults. 111
1Day Sooner @1daysooner.bsky.social · 30/03/2026We’re starting a new series called “Trials We Love,” in which we'll highlight clinical trials that our team is excited about! Our goal is to draw attention to opportunities to participate in research and share information about impactful trial results! 121
1Day Sooner @1daysooner.bsky.social · 03/03/2026We are HIRING! 1Day Sooner is hiring a Policy Lead to drive the policy agenda of our Clinical Trial Abundance (CTA) program. If this looks like you, please APPLY: 1daysooner.org/jobs/ 101
1Day Sooner @1daysooner.bsky.social · 03/03/2026The first legally binding global treaty on pandemic preparedness, the WHO Pandemic Agreement, was adopted in May 2025. A new BMJ Global Health analysis co-authored by 1Day's Zach Kafuko gh.bmj.com/content/11/2... argues that its success hinges on how Africa shapes implementation.gh.bmj.comThe WHO pandemic agreement—securing Africa’s leadership in a fragmenting global orderIn May 2025, the World Health Assembly adopted the historic WHO Pandemic Agreement, aimed at strengthening global pandemic preparedness and equity. This legally binding treaty emerged from years of ne... 111
1Day Sooner @1daysooner.bsky.social · 24/02/2026Last month, 1Day Sooner convened the first meeting of its Participant Council, bringing together 19 healthy research volunteers from 8 countries to help shape the future of clinical trial participation. 100
1Day Sooner @1daysooner.bsky.social · 12/02/2026Sub-Saharan Africa bears the highest global disease burden—yet <3% of clinical trials take place there, and very few are early-phase. That means key safety and dosing decisions are often made without data from the populations most affected. www.nature.com/articles/s44... 101
1Day Sooner @1daysooner.bsky.social · 05/02/2026The FDA’s decision to publish Complete Response Letters (CRLs) is a big step forward for transparency. Our new report explains how AI can help make this shift sustainable over time. 1daysooner.org/wp-content/u... 100
1Day Sooner @1daysooner.bsky.social · 23/01/2026Biotech loses an enormous amount of knowledge every year—and almost no one talks about it. When startups fail, their regulatory and clinical data usually disappears with them. A new initiative—called CTD Commons wants to change that. www.ctdcommons.orgctdcommons.orgHomeThe Mission The FDA holds a trove regulatory data and valuable scientific knowledge from thousands of failed biotech companies which could accelerate drug development if made accessible. The CTD Commo... 111
1Day Sooner @1daysooner.bsky.social · 08/01/20261Day Africa's grant program for African researchers is now accepting applications! Please share far and wide! The deadline for applications is February 28th. 000