In this study, Lee et al. demonstrate how a metabolite released by tissue damage, glutathione, instructs cells to embark on the first step of regeneration. Glutathione activates fast cell cycles in damaged plant organs, leading cells to rapidly change their identity to restructure a new organ.

Huang et al. demonstrate that plants use extracellular vesicles (EVs) to send defense proteins into fungal pathogens, thereby combating infection. They highlight the significance of protein transfer from plants to pathogens, a process that plays an important role in reducing crop diseases.