Here is what I have been up to in the lab of @stephangrill.bsky.social together with @neipel.bsky.social and many others.
Intrigued by avian left right symmetry breaking we found that a tissue-scale active torque drives chiral flow and requires mechanical coupling to the underlying tissue.
@neipel.bsky.social(1/10)
I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me.
doi.org/10.1101/2025...
doi.org
An active torque dipole across tissue layers drives avian left-right symmetry breaking
Unlike in mice, frogs, and fish, left-right (L/R) body axis formation in avian embryos does not arise from the chiral beat of cilia. Instead, a counter-clockwise tissue rotation around Hensen′ node, t...
