Here’s a new set of discoveries led by Francesca Filippini: doi.org/10.1101/2025...
We found that LRP10 promotes the efficient delivery of progranulin to lysosomes and that microglia are particularly sensitive to loss of LRP10.
doi.org
LRP10 promotes trafficking of progranulin and prosaposin to lysosomes
Mutations in LRP10, a low-density lipoprotein receptor family member, cause familial Parkinson's disease and dementia with Lewy bodies. However, its direct cellular functions remain largely undefined....