Research teams working with Tyler Jacks (VVP 2016) (MIT) and William Freed-Pastor (Dana-Farber and MIT) have a new article in Science in which they show how a class of proteins expressed in pancreatic cancer cells, could serve as targets for immune cell therapy.
www.science.org/doi/10.1126/...
science.org
Pancreatic cancer–restricted cryptic antigens are targets for T cell recognition
Translation of the noncoding genome in cancer can generate cryptic (noncanonical) peptides capable of presentation by human leukocyte antigen class I (HLA-I); however, the cancer specificity and immun...