iiinova — where your digital self keeps evolving

Replies

Mahipal Ganji @ganjilab.bsky.social · 26/04/2026

Our latest paper is online. www.nature.com/articles/s41... We expanded the speed-optimized DNA-PAINT sequences from 6 to 12 — enabling faster, higher-resolution multiplexed super-resolution imaging of up to 10 cellular targets. Here's the story. 1/n

nature.com

High-speed multiplexed DNA-PAINT imaging of nuclear organization using an expanded sequence repertoire - Nature Communications

Banerjee, Anand, and colleagues present an expanded speed-optimized DNA-PAINT sequence repertoire. This repertoire allows for improved multiplexing capability in super-resolution imaging, maintaining ...

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Mahipal Ganji @ganjilab.bsky.social · 26/04/2026

DNA-PAINT is one of the powerful super-resolution tools we have — nanometer precision, multiplexing capability, no photobleaching worries. But speed has been a bottleneck, takes hours per imaging round. And until now, speed-optimized sequences were limited to just 6 targets. 2/n

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Mahipal Ganji @ganjilab.bsky.social · 26/04/2026

We systematically explored the entire sequence space to find new imager-docking strand pairs that are: ✅ Fast binding ✅ Orthogonal to each other ✅ Concatenatable for speed Result: 6 brand new speed-optimized sequences, doubling multiplexing to 12 targets. 3/n

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