So many exciting papers and preprints in the past few weeks. This one is quite the tour de force!
@cedricboeckx.bsky.socialDelighted to share our new preprint, the outcome of many years of collaborative work with Giuseppe Testa’s group, both at the bench & in front of the computer, probing human brain evolution using organoids. We tried something cool, and learned a lot 🧪🧫🧠🧬
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www.biorxiv.org/content/10.1...
biorxiv.org
Regulatory logic of human cortex evolution by combinatorial perturbations
Comparative genomic studies between contemporary and extinct hominins revealed key evolutionary modifications, but their number has hampered a system level investigation of their combined roles in sca...