iiinova — where your digital self keeps evolving

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Anders Kiib @aekiib.bsky.social · 30/01/2025

Next, we found CHM-II to react with thiols both reversibly and irreversibly under preparative conditions and in aqueous buffers. An alkyne tagged CHM-II analogue allowed us to profile the amino acid selectivity using the workflow developed by the group of @stephanhacker2.bsky.social 5/7

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Anders Kiib @aekiib.bsky.social · 30/01/2025

The proteomic profiling (chemrxiv.org/engage/chemr...) showed CHM-II to be highly cysteine-selective, which combined with its small size, gives CHM-II potential as a new covalent reactive group 6/7

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Anders Kiib @aekiib.bsky.social · 30/01/2025

And much more! To prevent this “Bluetorial” from getting too long, I will refer you to the paper. Thank you to all co-authors, without whom the project would not have turned out as it did, and thank you for reading this far! 7/7

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