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ME/CFS Science @mecfsscience.org · 18/09/2026

7) My personal interpretation is that the sample sizes for these cohorts are too small and that the findings may mostly reflect noise or confounding. The results are much more uncertain, IMHO than those from DecodeME. More comments and analysis here:

s4me.info

Preprint - Seven replicated genomic associations of myalgic encephalomyelitis/chronic fatigue syndrome: a biobank study, 2026, Slaughter, Ponting et al. | Page 2 | Science for ME

I see it as a positive that this work was done and published. We know previous work on UK biobank data only identified one variant for females. It seems to...

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ME/CFS Science @mecfsscience.org · 18/09/2026

8 ) Some curious findings are - that they found so many significant hits for low sample size (n_eff = 5000) - that most of these hits involved minor allele frequency close to 1% - that the signals involve few correlated SNPs - that most (174/176) are protective against ME/CFS.

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ME/CFS Science @mecfsscience.org · 18/09/2026

9) An interesting aspect of this preprint is that they used a new analysis pipeline called TarGene. It also looked at the influence of sex (no significant interactions) and deprivation. The latter was higher in ME/CFS cases but showed no significant interactions either.

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Chris Ponting @cgatist.bsky.social · 22/09/2026

Some of this we can resolve: Human SNPs (on the array) are skewed towards being rare; few SNPs are correlated cos we didn’t use imputations; null/realistic simulations show TarGene’s good performance academic.oup.com/biostatistic... We think we know why most hits are protective & will update Thanks!

academic.oup.com

Semiparametric efficient estimation of small genetic effects in large-scale population cohorts

Summary. Population genetics seeks to quantify DNA variant associations with traits or diseases, as well as interactions among variants and with environmen

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