ME/CFS Science @mecfsscience.org · 18/09/20263) They found 1268 cases meeting this ME/CFS definition, which they could compare to more than 100.00 controls (who didn't have ME/CFS and reported good or excellent health). As the plot below shows, they found multiple DNA differences between the two groups. 170
ME/CFS Science @mecfsscience.org · 18/09/20264) They focused on 176 DNA letters that were significantly different (FDR < 0.05). Then they checked if those differences were also present in two other cohorts: - 319 ME/CFS other cases from the UK biobank (no overlap) - 371 ME/CFS cases from the All of US cohort in the US 180
ME/CFS Science @mecfsscience.org · 18/09/20265) That was the case for 7 signals, but as the results in Table 1 show, no signal was present in all three cohorts. 4 could be tested in DecodeME, and none had a p-value close to significance. So the replication was quite limited. 170