ME/CFS Science @mecfsscience.org · 18/09/20262) The preprint comes from Prof. Ponting's team at Edinburgh that also did DecodeME. This time, however, they selected ME/CFS cases from the UK Biobank. Participants had to self-report a CFS diagnosis and report a poor or fair overall health. 160
ME/CFS Science @mecfsscience.org · 18/09/20263) They found 1268 cases meeting this ME/CFS definition, which they could compare to more than 100.00 controls (who didn't have ME/CFS and reported good or excellent health). As the plot below shows, they found multiple DNA differences between the two groups. 170
ME/CFS Science @mecfsscience.org · 18/09/20264) They focused on 176 DNA letters that were significantly different (FDR < 0.05). Then they checked if those differences were also present in two other cohorts: - 319 ME/CFS other cases from the UK biobank (no overlap) - 371 ME/CFS cases from the All of US cohort in the US 180
