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ME/CFS Science @mecfsscience.org · 18/09/2026

1) A genetic analysis of the UK Biobank found 7 ME/CFS hits that were replicated in another cohort such as the All of Us cohort. One signal matched with expression of the gene CLYBL in the putamen brain region. But there are many caveats. None replicated in DecodeME.

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Sebastiaan Deetman @lymecfs.bsky.social · 18/09/2026

Oh, wow, seeing CLYBL show up here is very exciting! It's an enzyme that's also key to the Itaconate Shunt as hypothesized by a.o. dr. Rob Phair. m.youtube.com/watch?v=RiVD... Plus I have reason to believe the Itaconate Shunt can disregulate cortisol as suggested here: patientledhypothesis.github.io

m.youtube.com

Rob Phair, PhD, Presents on the Itaconate Shunt Hypothesis for ME/CFS

YouTube video by Open Medicine Foundation - OMF

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ME/CFS Science @mecfsscience.org · 18/09/2026

2) The preprint comes from Prof. Ponting's team at Edinburgh that also did DecodeME. This time, however, they selected ME/CFS cases from the UK Biobank. Participants had to self-report a CFS diagnosis and report a poor or fair overall health.

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H2oBio @h2obio.bsky.social · 18/09/2026

Wow. Interesting. GRIN2A interacts with Fyn and Src in the context of ischemia. Both kinases are also relevant in EBV and/or SARS-CoV-2 infection. Fyn is the target of quercetin (a mast cell stabilizer). RORA is relevant to the circadian rhythm.

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#LongCovid + #Philosophy (Wild Strain 2020) 🏳️‍⚧️🏳️‍🌈🩵 @be-herenow.bsky.social · 18/09/2026

Discuss the significance of the gene and how it manifests symptoms in the body.

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