ME/CFS Science @mecfsscience.org · 11/09/20267) On the lean test, 12% had POTS, 40% had postural orthostatic syndrome of hypocapnia (POSH) and another 8% had both POTS and POSH. These outcomes, however, were not related to total blood volume or RBCV. 190
ME/CFS Science @mecfsscience.org · 11/09/20268) The authors write: "These findings suggest that static blood volume deficits alone are unlikely to be the principal determinant of OI in ME/CFS" They also point to a 2001 trial of fludrocortisone, a drug that increases blood volume but which showed only limited benefit. 190
ME/CFS Science @mecfsscience.org · 11/09/20269) Many physician treat OI symptoms with saline infusions to increase blood volume. This study is a sign that this theory may be too simplistic. There are however, trials that will test more directly whether saline infusions work such as this OMF study:omfcanada.ngoSIMPLE Study: Impact of Saline Infusion on ME/CFS, POTS and Long COVID - Open Medicine Foundation CanadaComparing saline formulations' effectiveness in ME/CFS, Long COVID, and POTS patients to find the best types for patient improvement 2101
