ME/CFS Science @mecfsscience.org · 16/08/20261) Many of the genes linked to ME/CFS in DecodeME point to neural synapses. We therefore did an analysis using SynGo, a large database of synaptic genes. Experts in the field grouped these genes into multiple categories based on their location or biological function. 1309
ME/CFS Science @mecfsscience.org · 16/08/20262) The genes associated with ME/CFS were enriched in several of these synaptic categories. Here's what the main result looks like. The table shows the names of the categories, the number of genes, and the P-values associated with them. 180
ME/CFS Science @mecfsscience.org · 16/08/20263) The results mostly point to the postsynaptic assembly and scaffolding at the membrane, so more about how synapses get built and wired rather than how they fire and release neurotransmitters. 391