ME/CFS Science @mecfsscience.org · 11/07/20264) The negative result was clearest for the anticoagulant rivaroxaban (difference: –1·06 [95% confidence interval: –2·47 to 0·35]; p-value= 0·139). This finding questions whether blood clotting is a relevant factor in Long Covid patients. 150
ME/CFS Science @mecfsscience.org · 11/07/20265) The paper is more optimistic about colchicine and antihistamines, but the results are pretty clear. The confidence interval is fully below 3 points. colchicine (–1·49 points [95% CI –2·92 to –0·06]; p=0·041) famotidine + loratadine (–1·48 [95% CI –2·88 to –0·08]; p=0·038) 170
ME/CFS Science @mecfsscience.org · 11/07/20266) So I think these treatments also had largely null results. This could be because LC is very heterogeneous. On the other hand, with around 200 patients per treatment arm, the sample size was quite large, so it could have picked up on relevant subgroups. 180
