iiinova — where your digital self keeps evolving

Replies

ME/CFS Science @mecfsscience.org · 08/06/2026

2) MMP-9 was measured in serum (not in plasma) and there's a literature explaining why this isn't a reliable method. MMP-9 is released during the sampling and clotting proces used to make serum. Links: www.nature.com/artic... pmc.ncbi.nlm.nih.gov...

nature.com

Is serum matrix metalloproteinase 9 a useful biomarker in detection of colorectal cancer? Considering pre-analytical interference that may influence diagnostic accuracy

British Journal of Cancer - Is serum matrix metalloproteinase 9 a useful biomarker in detection of colorectal cancer? Considering pre-analytical interference that may influence diagnostic accuracy

190

ME/CFS Science @mecfsscience.org · 08/06/2026

3) One paper concluded for example "MMPs are released by platelets or leukocytes during platelet activation or sampling process, thus leading to artificially higher MMP-9 levels in serum..."

sciencedirect.com

Rapid separation of serum does not avoid artificially higher matrix metalloproteinase (MMP)-9 levels in serum versus plasma

To examine whether the time between blood drawing and centrifugation (TBDC) affects the levels of matrix metalloproteinase (MMP)-9 and MMP-2 levels in…

170

ME/CFS Science @mecfsscience.org · 08/06/2026

4) The samples of ME/CFS patients and controls in this study were also handled and collected very differently. Patients were recruited at the University of Miami while the control samples were taken from an external biobank (bioBioIvt Elevating Science).

190