iiinova — where your digital self keeps evolving

Replies

ME/CFS Science @mecfsscience.org · 04/06/2026

2) This new paper by Natelson’s team doesn’t fully reverse that. It’s not the biggest study on this topic and most previous studies did find an effect. See reviews here and here: pmc.ncbi.nlm.nih.gov/articles/PMC... www.tandfonline.com/doi/full/10....

pmc.ncbi.nlm.nih.gov

The Prospects of the Two-Day Cardiopulmonary Exercise Test (CPET) in ME/CFS Patients: A Meta-Analysis

Background: The diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is problematic due to the lack of established objective measurements. Postexertional malaise (PEM) is a hallmar...

270

ME/CFS Science @mecfsscience.org · 04/06/2026

3) That said, we did a deep-dive into the 2-day CPET literature in ME/CFS, and the evidence is not that strong. Most were small studies with some inconsistencies or retrospective data from clinical practice. mecfsscience.org/discrepancie...

mecfsscience.org

Discrepancies in 2-day exercise studies - ME/CFS Science

Repeated exercise tests have been one of the most intriguing topics of research on myalgicContinue readingDiscrepancies in 2-day exercise studies

180

ME/CFS Science @mecfsscience.org · 04/06/2026

4) The biggest problem I see is with claims that the 2-day CPET protocol is an objective test for PEM (some even call it the ‘gold standard’, see screenshot below). There simply haven’t been any studies that tested how these two are related.

160