ME/CFS Science @mecfsscience.org · 30/05/202616) Another interesting finding: mice that got LC antibodies had a reduction in intraepidermal nerve fiber (IENF) in the dorsal root ganglion, a marker for small fiber neuropathy. 290
ME/CFS Science @mecfsscience.org · 30/05/202617) They also measured brain-wide neuronal activity and report activation of brain regions associated with pain and fatigue, although this is a bit more speculative (hard to interpret what brain regions and signaling mean). 180
ME/CFS Science @mecfsscience.org · 30/05/202618) Overall, this is an impressive, in-depth paper providing evidence for autoimmunity in a subset of LC patients. But a decisive result of identifying a specific antibody that is pathological and causes symptoms, wasn’t achieved (yet). 3122
