ME/CFS Science @mecfsscience.org · 06/05/20265) They are confident the bimodal onset pattern exists because they found it in multiple data sources: the Norwegian healthcare data, the European survey and the DecodeME study. These have different biases, yet the pattern remained the same. 2150
ME/CFS Science @mecfsscience.org · 06/05/20266) Interestingly, there wasn't a big difference between men and women in the onset pattern. If it were hormonal changes for example, we would expect to find a sex difference as well but that wasn’t the case. 2170
Simon McGrath @simonmcg.bsky.social · 06/05/2026Looking forward to seeing the DecodeME X chromosome analysis, which should throw light on any sex differences. 010
ME/CFS Science @mecfsscience.org · 06/05/20267) They did find that people in the early onset are more severely affected, have more family members with ME/CFS and are more likely to report an infectious trigger. The latter was particularly the case for glandular fever although this didn’t fully explain the difference. 1150
