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ME/CFS Science @mecfsscience.org · 03/04/2026

5) There were around 100 patients per group for each comparison. Primary outcome was assessed at follow-up, 90 days after starting treatment. We'll focus on the treatment group that received the full 25 days of Paxlovid (results were similar for the group that got 15 days).

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ME/CFS Science @mecfsscience.org · 03/04/2026

6) The COGNITIVE group tested the percentage that improved by 5 points or more on the PROMIS Cognitive 8a questionnaire T scale. This was 57.8% in the Paxlovid and 54.6% in the placebo group. The difference was not statistically significant (p-value = 0.646).

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ME/CFS Science @mecfsscience.org · 03/04/2026

7) There was also an objective outcome: the Neurocognitive Battery (a series of cognitive tests). The percentage with a meaningful improvement here was 9.8% in the Paxlovid group and 14.3% in the placebo group (p-value: 0.317).

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