ME/CFS Science @mecfsscience.org · 14/02/20264) But there was a paradox in this study. TGF-β was increased but didn't correlate with ME/CFS severity. Some inflammatory cytokines such as IFN-gamma did correlate with ME/CFS severity but levels were similar to controls. 2130 13
ME/CFS Science @mecfsscience.org · 14/02/20265) Another major study was done by Mady Hornig and colleagues at Columbia, published in 2015. It had a large sample size: 298 patients and 348 controls. Here, patients often had lower levels of circulating cytokines. Link: www.science.org/doi/10.1126/...science.orgDistinct plasma immune signatures in ME/CFS are present early in the course of illnessCytokine alterations are more strongly correlated with illness duration than with measures of illness severity. 1100 10
ME/CFS Science @mecfsscience.org · 14/02/20266) But zooming in, the researchers found a pattern: patients with a short illness duration (≤3 years) did have increased cytokine levels than controls while those with long duration had lower levels. 1110 11
