ME/CFS Science @mecfsscience.org · 18/10/20252) The hypothesis states that the normal TCA cycle to generate energy is disrupted during an infection. A gene called ACOD1 diverts the metabolites away from the cycle towards the Itaconate pathway, making it less efficient in producing energy. 270
ME/CFS Science @mecfsscience.org · 18/10/20253) Peterson and his team managed to create zebrafish larvae where the gene ACOD1is overexpressed. They then did several behavioural experiments in fish with and without the gene change. 170
ME/CFS Science @mecfsscience.org · 18/10/20254) In tests with lights or vibration as stimuli being turned on and off, the zebrafish with ACOD1 overexpression had approximately a 40% reduction in movement compared to controls. They also had reduced oxygen consumption. 160
