ME/CFS Science @mecfsscience.org · 13/01/20254) They way key symptoms were assessed is also quite problematic. PEM was assessed by asking if patients had: ‘“post-exertional malaise (symptoms worse after even minor physical or mental effort)”. 150
ME/CFS Science @mecfsscience.org · 13/01/20255) This is quite vague as it doesn’t define which symptoms get worse, how long after the effort, and if it caused additional functional impairment. It was also a yes/no question, severity of PEM was not measured. 150
ME/CFS Science @mecfsscience.org · 13/01/20256) Orthostatic intolerance was queried by asking if participants had the following: “Feeling faint, dizzy, ‘goofy’; difficulty thinking soon after standing up from a sitting or lying position” 140
