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Prof. Shane Crotty @profshanecrotty.bsky.social · 20/10/2025

In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/... @scienceimmuno.bsky.social @lji.org

science.org

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates

Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.

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Prof. Shane Crotty @profshanecrotty.bsky.social · 20/10/2025

An effective HIV vaccine will likely need to elicit multiple bnAb classes simultaneously. In this study, we systematically tested whether different combinations of three HIV GT immunogens could prime bnAb-class responses. Turns out, the immune system can handle multitasking just fine.

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Prof. Shane Crotty @profshanecrotty.bsky.social · 20/10/2025

We isolated a total of 13 BG18-class (V3/glycan), 84 PCT64-class (Apex), and 134 10E8-class (MPER) unique clonal lineages from primates that received a triple combination GT immunization regimen. To our knowledge, this is the first report of its kind.

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