Prof. Shane Crotty @profshanecrotty.bsky.social · 30/07/2025www.statnews.com/2025/07/30/m...statnews.comUsing mRNA, scientists overcome a key challenge to HIV vaccinesScientists used a mRNA-based vaccine to reliably trigger antibodies that block HIV infection in people and monkeys 131
Prof. Shane Crotty @profshanecrotty.bsky.social · 30/07/2025“The field has made enormous progress in the last two or three years, and this is a reward for the investments that the federal government has made in these programs,” said Dennis Burton, @scripps.edu . “Now is not the time to end these efforts,” warned Burton. 100
Prof. Shane Crotty @profshanecrotty.bsky.social · 30/07/2025bsky.app/profile/prof...Prof. Shane Crotty@profshanecrotty.bsky.socialAfter 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people. * "Tier 2" neutralizing antibodies, induced consistently. www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...science.orgVaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal modelsAn HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models. 000