Michel Nivard @michelnivard.bsky.social · 13/05/2026Is this plot mislabeled or am I just reading it wrong in some way? it appears genebass has more power than the new meta looking at the missense class in particular? 100 0
Konrad @konradjk.bsky.social · 13/05/2026Well it’s a bit funky. For better or for worse, we did 1% max MAF in UKB (all that was easily accessible) and 0.1% in AoU, which makes things very different esp for the missense/synonymous space. I tend to focus on the pLoF partially for this reason and that the effect directions are consistent 010 0
