iiinova — where your digital self keeps evolving

Replies

Manuel Irimia @mirimiam.bsky.social · 28/04/2025

💥 We studied zebrafish mutants lacking the srrm3 eMIC domain (essential for microexon inclusion). These srrm3∆eMIC larvae showed: hyperlocomotion, severe sleep loss, anxiety-like behaviours and sensory hypersensitivity - all pointing to hyper-arousal! 4/9

130

Manuel Irimia @mirimiam.bsky.social · 28/04/2025

🐟 Using high-speed tracking, we found that srrm3∆eMIC larvae more frequently engage in high-displacement, stress-associated swims - even without any stimulus. They also showed seizure-like episodes: prolonged, atypical swim bouts with hyperkinetic features. 5/9

120

Manuel Irimia @mirimiam.bsky.social · 28/04/2025

🧠 Zooming into the brain with 2P calcium imaging: srrm3∆eMIC mutant neurons were hyperactive, and forebrain activity remained elevated even during stress-inducing visual stimuli - despite reduced visually-evoked responses (due to known photoreceptor loss). 6/9

120