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Manuel Irimia @mirimiam.bsky.social · 30/12/2024

🐟 Our new paper "Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish" is out in @elife.bsky.social 🐟 A nearly 10-year tour-de-force by Laura Lopez-Blanch and many others in the lab @crg.eu & @upf.edu elifesciences.org/reviewed-pre... Thread 👇1/9

elifesciences.org

Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

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Manuel Irimia @mirimiam.bsky.social · 30/12/2024

Microexons display striking conservation and switch-like regulation in neurons by the splicing factors Srrm3 and Srrm4. Consequently, disruption of these regulators leads to severe neurological phenotypes in mice, and their misregulation is linked to human disease. 2/9

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Manuel Irimia @mirimiam.bsky.social · 30/12/2024

However, the specific microexons behind these phenotypes and the effects of individual microexon deletions on neurodevelopment, physiology, and behavior remain poorly understood. 3/9

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