Absolutely gorgeous and meticulous work from @juliabrunner.bsky.social that has been so fun to brainstorm about over the years. Another important reminder that even ‘core’ metabolic pathways are often differentially wired across cell states!
@juliabrunner.bsky.socialA big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/
cell.com
Aspartate availability drives differential engagement of the malate-aspartate shuttle
Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent
and can be modulated by the availability of the amino acid aspartate. In differentiated
cells, malate-aspartate s...