IOCB Prague @iocbprague.bsky.social · 05/10/2026This enabled the synthesis of structurally and stereochemically diverse atropopeptides inspired by naturally occurring ribosomally synthesized and post-translationally modified peptides (RiPPs), known as RiPPs. 100
IOCB Prague @iocbprague.bsky.social · 05/10/2026 Preparation of these cyclic peptides will enable bioactivity screenings in search of compounds with anticancer and antibacterial properties. Such studies will also shed light on the impact of atropisomerism on the molecules’ pharmacological properties. 100
IOCB Prague @iocbprague.bsky.social · 05/10/2026The work impacts synthesis and catalysis broadly. It brings attention to a new way of synthesizing cyclic heterobiaryl molecular architectures available for drug discovery, and to a concept in catalysis which is to inspire other challenging and useful substitution and addition reactions. 100
