IOCB Prague @iocbprague.bsky.social · 05/10/2026Many of the resulting compounds have three-dimensional shapes and stereochemistry that are of particular interest in medicinal chemistry. The researchers applied the reaction to direct cyclization of tryptophan-containing peptides. 100 0
IOCB Prague @iocbprague.bsky.social · 05/10/2026This enabled the synthesis of structurally and stereochemically diverse atropopeptides inspired by naturally occurring ribosomally synthesized and post-translationally modified peptides (RiPPs), known as RiPPs. 100 0
IOCB Prague @iocbprague.bsky.social · 05/10/2026 Preparation of these cyclic peptides will enable bioactivity screenings in search of compounds with anticancer and antibacterial properties. Such studies will also shed light on the impact of atropisomerism on the molecules’ pharmacological properties. 100 0
