Reading this made my day! Elegant experiments, convincing data and a crazy mechanism: Fuel switch and adrenergic stimulation converge on intra-mitochondrial calcium that induces mito swelling to physically release mitos from LDs. This enhances lipolysis by increasing LD accessibility to lipases 🤯
@embojournal.orgMitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets - facilitating lipolysis during thermogenesis
Israel Sekler, Orian Shirihai and collaborators
link.springer.com/article/10.1...
link.springer.com
Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets - The EMBO Journal
Adrenergic stimulation of brown adipocytes induces a robust detachment of mitochondria from lipid droplets (LD), which is followed by lipolysis and lipid catabolism. However, the signals inducing mito...
