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Laura Lorenzo-Sanz @lauralorenzos.bsky.social · 21/11/2024

Extremely happy to share my first-author paper out in #NatureCommunications dissecting how the epithelial-mesenchymal plasticity of cancer cells influences immunotherapy response! @natureportfolio.bsky.social ➡️ www.nature.com/articles/s41...

nature.com

Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma - Nature Communications

Immune surveillance is critical to prevent the development and progression of cutaneous squamous cell carcinoma (cSCC). Here, the authors show that epithelial-mesenchymal plasticity in cancer cells is...

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Tim Robinson @drtimrobinson.bsky.social · 21/11/2024

Bravo, great paper. Lots of emerging data for the PD1/TIGIT combo in the lab but data from lung trials has been disappointing. I hope that new strategies, with chemo or ADC backbones, may help circumvent this resistance. We know cytotoxics induce CSCs and it needs exploring

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Laura Lorenzo-Sanz @lauralorenzos.bsky.social · 22/11/2024

It's true that the #TIGIT space has seen ups and downs in the last few years. Curious to see clinical trials implementing better patient stratification strategies based on epithelial/mesenchymal markers to improve responses to #immunotherapy!

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