Roger Struble, MD, MPH @jazzscrubs.bsky.social · 02/12/2024The numbers: Mortality: 14.5% (7 days) vs. 16.1% (14 days) C. diff rates? Same. No harm detected in most subgroups, though confidence intervals were wide in some (e.g., gram-positive infections, high frailty scores). 🤔 100
Roger Struble, MD, MPH @jazzscrubs.bsky.social · 02/12/2024Before you start ordering 7-day courses for everyone, here’s the fine print: Staph aureus? Excluded. Indwelling devices? Excluded. Severely immunocompromised? Yep, excluded. This is for gram-negative bacteremia without major complications. Keep your judgment hat on. 🧠👨⚕️ 110
Roger Struble, MD, MPH @jazzscrubs.bsky.social · 02/12/2024Real-world reality check: 23% of "7-day" patients got extra antibiotics anyway (vs. 11% in the 14-day group). Docs often extended treatment based on clinical judgment. This trial supports shorter intended courses, not rigid rules. ⚖️ 140
