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#Sciences

30 posts

Science Magazine @science.org · 10h

A biochemical deep dive deciphers how the same enzyme has contrasting effects on cancer growth, researchers build a global map of how light remodels phosphorylation in the eye of the fruit fly, and more in the new issue of #ScienceSignaling. scim.ag/3VdwiwU

The image is a colored scanning electron micrograph of the ommatidia and setae in a Drosophila compound eye.

Credit: Dennis Kunkel Microscopy/Science Source

Science Magazine @science.org · 25/09/2026

New results in #ScienceSignaling reveal that the T cell adaptor protein PAG supports the function of #TCell immune synapses by connecting with actin, suggesting that it could offer a target to improve #immunotherapy in patients that show poor responses. scim.ag/3V1ilCa

PAG supports T cell immune synapse function by binding to actin

A plasma membrane adaptor protein supports cytotoxic T cell function by connecting with the actin network.

Science Magazine @science.org · 23/09/2026

A new proximity labeling and biophysical analysis shows that the protein Girdin-L is an unexpected ligand of the PDZ domain of the Dishevelled protein and plays an important role in promoting the breakdown of primary cilia on cells. #ScienceSignaling scim.ag/47koCeN

Dishevelled drives disassembly of primary cilia through an unusual PDZ domain–mediated binding mode with Girdin-L

Girdin binds to the PDZ domain of Dishevelled to promote cilium disassembly.

Science Magazine @science.org · 22/09/2026

The new issue of #ScienceSignaling is out! Research reveals how Girdin binds to Dishevelled to promote the disassembly of cilia, experiments reveal how a T cell adaptor protein supports cytotoxic T cells by connecting with actin, and more. scim.ag/4dSEzN0

The cover shows H&E-stained ear tissue from mice.

Credit: Moore et al./Science Signaling

Science Magazine @science.org · 18/09/2026

In a new Focus in #ScienceSignaling, scientists examine pioneering results from a recent paper in #ScienceMagazine, which decoded how #viruses co-opt the ubiquitin-proteasome system in host cells to interfere with innate immune defenses. scim.ag/46ViQAb

Viral hijacking of the host ubiquitin-proteasome system for immune escape

How viruses manipulate the host ubiquitin-proteasome system to their advantage is revealed.

Science Magazine @science.org · 16/09/2026

Using advanced protein tagging techniques, researchers have made new discoveries about the assorted members of a protein #interactome that guides signaling in cells in the #lymphatic system, which could inform novel therapeutics. #ScienceSignaling scim.ag/4hqlbJo

The image is a light micrograph of a lymph vessel.

Science Magazine @science.org · 15/09/2026

The new issue of #ScienceSignaling is out! Proteomics identifies an unexpected member of the adrenomedullin receptor interactome in lymphatic endothelial cells, a new Focus explores a pioneering study in Science decoding how viruses co-opt host cells, and more. scim.ag/4As9k5k

The 15 September 2026 cover of Science Signaling. The image is a light micrograph of a lymph vessel.

Science Magazine @science.org · 10/09/2026

A tumor’s specific #NRAS mutation could determine the best course for therapy in NRAS-mutant cancers, according to new work in #ScienceSignaling. scim.ag/3TmPDuQ

HRAS promotes mutant NRAS–driven transformation with codon and allele specificity

Effectively treating NRAS-mutant cancers may require a combined pan-RAS and HRAS-specific strategy.

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Science Magazine @science.org · 09/09/2026

In a new #ScienceSignaling paper, scientists have found that the notorious pathogen C. difficile, the cause of many hospital-acquired infections, can detoxify bacitracin to colonize the gut. scim.ag/4cC5bBw

The image is a colorized electron micrograph of sporulating C. difficile.

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Science Magazine @science.org · 08/09/2026

This week’s new issue of #ScienceSignaling has arrived! scim.ag/4icvn9o

The latest Science Signaling cover for the 8 September 2026 issue. The image is a colorized electron micrograph of sporulating C. difficile.

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Science Magazine @science.org · 03/09/2026

In a new #ScienceSignaling Review, researchers discuss recent structural and functional studies of aGPCR activation that suggest two main activation mechanisms for these receptors. Learn more: scim.ag/4h5GMFZ

Reexamining the activation mechanisms of adhesion G protein–coupled receptors

Structural and functional data support a unified, context-dependent model of aGPCR activation.

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Science Magazine @science.org · 02/09/2026

ORAI calcium ion channels and the channel regulator STIM1 in capillary endothelial cells are needed to adjust blood flow to support sustained neuronal activity. Deficiencies in these proteins led to dementia-like symptoms in mice. Learn more in #ScienceSignaling: scim.ag/4cjOk6n

ORAI Ca2+ channels and STIM1 drive capillary-to-arteriole communication in neurovascular coupling

Sustained cerebral arteriole dilation requires ORAI1-mediated Ca2+ influx in capillary endothelial cells.

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Science Magazine @science.org · 01/09/2026

This week’s new issue of #ScienceSignaling has arrived! scim.ag/4yb8rMi

The image shows the parenchymal arterioles and the surrounding capillary network of the cerebral microvasculature, with endothelial cells in magenta and other vascular cell types in cyan.

Credit: B. Lavanderos/University of Rochester Medical Center, USA

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Science Magazine @science.org · 28/08/2026

Although neurons are often categorized by brain location, a new #ScienceSignaling study in mice reveals classifying VTA dopaminergic neurons by glutamate transmission can better predict their properties and role in learning and reward-motivated behavior. scim.ag/4zjPQ21

Distinct properties of glutamate-dopamine, nonglutamate-dopamine, and glutamate-only ventral tegmental area neurons

Glutamate cotransmission predicts the behavioral functions and characteristics of dopaminergic neurons in the VTA.

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Science Magazine @science.org · 26/08/2026

An enzyme named BRAF acts as a molecular amplifier of neuropathic pain after nerve injury by migrating to synapses in spinal neurons, shows new preclinical work that also identifies BRAF inhibitors as promising therapies. Learn more in #ScienceSignaling: scim.ag/4zEaPwE

BRAF recruitment to spinal sensory synapses promotes neuropathic pain by potentiating transsynaptic NMDA receptor activity

Blocking the kinase BRAF reduces nociceptive transmission in spinal cord after injury.

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Science Magazine @science.org · 25/08/2026

This week’s new issue of #ScienceSignaling has arrived! scim.ag/4wI0NIf

The image shows the detection of BRAF (green) and a neurofilament (red) in dorsal root ganglia from mice.

Credit: Jin et al./Science Signaling

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Science Magazine @science.org · 21/08/2026

CRISPR-based experiments build a more complete picture of the regulation of interferon responses, which may inform the development of treatments for immunodeficiencies or inflammatory disorders linked to aberrant IFN production. #ScienceSignaling scim.ag/4qth02y

A genome-wide map of the genetic network in monocytes that regulates type I interferon induction by the cGAS-STING pathway

Genetic screens identify context-dependent regulators of STING-driven IFN-β induction in monocytes.

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Science Magazine @science.org · 19/08/2026

New work in #ScienceSignaling shows that neurons in the brain’s VTA region can be classified by their associated neurotransmitters—a finding that reshapes our understanding of these cells and may inform treatments for psychiatric conditions such as addiction. scim.ag/4zjPQ21

Distinct properties of glutamate-dopamine, nonglutamate-dopamine, and glutamate-only ventral tegmental area neurons

Glutamate cotransmission predicts the behavioral functions and characteristics of dopaminergic neurons in the VTA.

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Science Magazine @science.org · 18/08/2026

Don’t miss this week’s new issue of #ScienceSignaling! A more nuanced paradigm of neurons in the brain’s reward area could reshape the study of learning, CRISPR experiments provide a resource to interrogate interferon signaling, and more. scim.ag/4bWODnv

The image shows a midbrain section from a mouse line in which glutamate-dopamine neurons (yellow) in the VTA have been genetically targeted.

Credit: Prévost et al./Science Signaling

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Science Magazine @science.org · 14/08/2026

An emerging body of work shows that #glial cells act as leading architects of the neural extracellular matrix, which serves as a critical signaling hub for nerve synapses and neuronal circuits, according to a new Focus in #ScienceSignaling. scim.ag/3UasbB2

Beyond the scaffold: Glia as architects of the neural extracellular matrix

How glial cells dynamically shape their surroundings provides insight into brain development and aging.

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Science Magazine @science.org · 12/08/2026

Although omega fatty acids are famous for their health benefits, new #ScienceSignaling experiments in mice show that some omega fatty acids can suppress the cancer-killing capabilities of natural killer cells by acting through a receptor named LRP5. scim.ag/4wObauU

LRP5-dependent transport of polyunsaturated fatty acids serves as an immune checkpoint for natural killer cells

Polyunsaturated fatty acids curb NK cell function and immunotherapy efficacy against colon cancer in mice.

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Science Magazine @science.org · 11/08/2026

The new issue of #ScienceSignaling has arrived! A preclinical study suggests some omega fatty acids can disrupt antitumor immunity, a Focus explores discoveries about the architectural role of glial cells in the neural extracellular matrix, and more. scim.ag/4fYV62b

The image is a colored scanning electron micrograph of a natural killer cell.

Credit: Steve Gschmeissner/Science Source

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Social Media Lab @socialmedialab.ca · 11/08/2026

Calling all social media researchers: In addition to existing data collectors, @Communalytic.org can now collect data from the following data sources: - TikTok & - Telegram communalytic.org/2026/02/18/c... #polsky #academicsky #comsky #sciencesky #phdsky

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Science Magazine @science.org · 07/08/2026

An RNA editing enzyme restrains the excessive proliferation of intestinal stem cells—a major hallmark of #aging in humans and other organisms—according to recent work in #ScienceSignaling involving fruit flies and data from mice and human samples. scim.ag/4g2RNr3

A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging

The RNA editing enzyme ADAR slows intestinal stem cell aging by reducing proliferative MAPK signaling.

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Science Magazine @science.org · 06/08/2026

New experiments identify a receptor that helps regenerate the brain’s white matter after #stroke—and reveal that activating this receptor enhances cognitive and motor recovery in mice by stimulating “clean up” cells called microglia. #ScienceSignaling scim.ag/456KI3v

Adenosine 2A receptor drives microglial efferocytosis to accelerate white matter repair and functional recovery after stroke

Stimulating the efferocytosis of cellular and myelin debris by microglia after stroke promotes remyelination.

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Science Magazine @science.org · 04/08/2026

Don’t miss this week’s issue of #ScienceSignaling, featuring new discoveries about how a receptor found on “clean-up” microglial cells can be targeted to foster cognitive and motor recovery after stroke in mice. scim.ag/4fPyzFc

The single-cell 3D reconstructions show microglia (red) from mice treated with control (top) or agonist-containing (bottom) micelles engulfing myelin (blue) within lysosomes (green).

Credit: Deng et al./Science Signaling

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Science Magazine @science.org · 31/07/2026

By leveraging strategic chemical design, researchers have designed an analog of the #psychedelic drug quipazine to produce fewer gastrointestinal side effects in mice while maintaining its ability to alleviate depression-like behaviors. #ScienceSignaling scim.ag/3RN4xK4

Design of a new psychedelic quipazine analog with therapeutic efficacy and potentially fewer side effects

A psychedelic derivative promotes synaptic and behavioral plasticity without affecting GI motility.

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Science Magazine @science.org · 29/07/2026

An RNA editing enzyme restrains the excessive proliferation of intestinal stem cells—a major hallmark of #aging in humans and other organisms—according to new work in #ScienceSignaling involving fruit flies and data from mice and human samples. scim.ag/44VKex1

A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging

The RNA editing enzyme ADAR slows intestinal stem cell aging by reducing proliferative MAPK signaling.

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Science Magazine @science.org · 28/07/2026

Don’t miss this week’s new issue of #ScienceSignaling! Scientists trace how an RNA-editing enzyme restrains a hallmark of aging in intestinal stem cells, our Editors’ Choice piece considers recent findings about how stress induces senescence, and more. scim.ag/4pThn6b

The image shows a midgut from a young fly in which intestinal stem cells are labeled in green and red and nuclei are stained blue.

Credit: Zhang et al./Science Signaling

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Science Magazine @science.org · 24/07/2026

High expression of NDRG1 in cancers supports DNA damage repair, according to new work that also reveals how mutations in other DNA repair genes can render tumors vulnerable to NDRG1-disrupting drugs such as quinacrine. #ScienceSignaling scim.ag/4fehIg8

NDRG1 expression in cancers confers dependence on DNA damage repair and sensitivity to quinacrine

High-throughput screens reveal therapeutic vulnerabilities around the stress-response protein NDRG1 in cancer.

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