iiinova — where your digital self keeps evolving

Reposted by Syed Zawar Shah

Joachim Frank @joachim123.bsky.social · 16/01/2025

You want to build an apparatus for time-resolved cryo-EM? Easy: bio-protocol.org/en/bpdetail?...

bio-protocol.org

14215

Reposted by Syed Zawar Shah

Cees Dekker @ceesdekker.bsky.social · 16/01/2025

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

210532

Reposted by Syed Zawar Shah

Alessandro Vannini @alessandrovannini.bsky.social · 03/01/2025

Excited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41... A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work

nature.com

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters - Nature Communications

The snRNA Activating Protein Complex (SNAPc) mediates snRNA transcription by RNA Pol II and III. Here, the authors have used cryo-EM to resolve the structure of the SNAPc-bound RNA Pol III pre-initiat...

45219