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Zachary L. Smith, DO, MSc. (Oxon)

@zachsmithgi.bsky.social
180 followers 146 following 10 posts

Academic Gastroenterologist and Clinical Trialist

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Zachary L. Smith, DO, MSc. (Oxon) @zachsmithgi.bsky.social · 24/02/2026
This clip from @profgalloway.com resonates with something I recently wrote about rejection in academic medicine. substack.com/@trialisttri...
substack.com
We Regret to Inform You...
Lessons from the rejection pile
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Zachary L. Smith, DO, MSc. (Oxon) @zachsmithgi.bsky.social · 20/02/2026
Circling back to this a year later… @ebtapper.bsky.social I would argue that the data itself is good but it MUST be handled at the IPD level by statistical experts. I think >95% of studies using aggregate data and the TriNetX UI analytics are not believable. www.cghjournal.org/article/S154...
cghjournal.org
Uncomplicated Choledocholithiasis in Elderly Patients: A Target Trial Emulation Comparing Observation and ERCP (CHOIcE)
The management of uncomplicated choledocholithiasis in elderly patients remains controversial due to uncertain clinical benefits of intervention and higher complication rates with endoscopic retrograd...
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Zachary L. Smith, DO, MSc. (Oxon) @zachsmithgi.bsky.social · 20/02/2026
open.substack.com/pub/trialist...
open.substack.com
We Regret to Inform You...
Lessons from the rejection pile
000
Zachary L. Smith, DO, MSc. (Oxon) @zachsmithgi.bsky.social · 05/10/2025
open.substack.com/pub/trialist...
open.substack.com
The Opportunity Cost of Status Quo Science
Why innovation in trial design matters for patients, clinicians, and the future of medicine
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Zachary L. Smith, DO, MSc. (Oxon) @zachsmithgi.bsky.social · 24/07/2025
open.substack.com/pub/trialist...
open.substack.com
Content being content: Tuning out the unrest of others
TTT goes a bit sentimental about career mobility, institutional fit, and the quiet power of support
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Zachary L. Smith, DO, MSc. (Oxon) @zachsmithgi.bsky.social · 24/07/2025
substack.com/@trialisttri...
substack.com
Time to RESUME: Rekindling Trialist Tribulations
Charting a new course for RESUME after PCORI—and amid the current political climate
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Zachary L. Smith, DO, MSc. (Oxon) @zachsmithgi.bsky.social · 06/02/2025
Researchers, trialists, and all, I've started a Substack publication called The Trialist Tribulations. The first edition drops tonight. I'd be grateful if you gave it a read. Please consider subscribing if you don't hate it. 🤞 #MedSky #AcademicSky #GISky open.substack.com/pub/trialist...
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Zachary L. Smith, DO, MSc. (Oxon) @zachsmithgi.bsky.social · 31/01/2025
open.substack.com/pub/trialist...
open.substack.com
Coming soon: The Trialist Tribulations
The Trialist Tribulations is a new publication consisting of "weekly musings from the world of academic medicine."
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