Proteins have evolved over billions of years through extensive and coordinated substitutions, insertions and deletions (indels). Computational protein design cannot yet fully mimic nature's ability to...

AbstractSummary. Although knowing where a protein functions in a cell is important to characterize biological processes, this information remains unavailab

The majority of genetic variants identified in genome-wide association studies of complex traits are non-coding, and characterizing their function remains an important challenge in human genetics. Gen...