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Yosef (Yossi) Buganim

@yossibuganim.bsky.social

Scientist, interested in epigenetic reprogramming, cellular rejuvenation, and embryogenesis. Head of a stem cell lab at the Hebrew University of Jerusalem and co-founder and CSO at Ananda Labs www.buganimlab.com www.ananda-labs.bio

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 10/01/2025

Congrats Yaniv and team

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 18/12/2024

Thank you Yaniv!

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 18/12/2024

@stemcells.bsky.social

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 18/12/2024

(4/n) Huge kudos to the amazing members of the Buganim and Soufi labs for their incredible efforts! 🙌 I truly believe this work redefines our understanding of how cell type-specific gene expression is orchestrated and how cell fate determination is established. 🌟

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 18/12/2024

(3/n) Our study reveals that transcription factor combinations use distinct strategies to locate enhancers: • OSKM factors leverage motif orientation within chromatin loops to target pluripotent enhancers. • GETM factors use looping junctions to locate trophectoderm enhancers.

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 18/12/2024

(2/n) We identified a previously uncharacterized DNA element adjacent to enhancers, which we’ve termed the "signpost." This element facilitates transcription factor binding near enhancers, enabling precise targeting and activation.

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 18/12/2024

www.nature.com/articles/s41... (1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀 Check out our latest collaborative work with the Soufi lab, now published in @Nature

nature.com

Nucleosome fibre topology guides transcription factor binding to enhancers - Nature

Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 18/12/2024

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 22/11/2024

www.pnas.org/doi/10.1073/... Happy to share our recent collaborative study with the Cedar and Stanger labs, identifying the barrier responsible for incomplete epigenetic reprogramming in both in vitro and in vivo transdifferentiation models.

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Yosef (Yossi) Buganim @yossibuganim.bsky.social · 22/11/2024

Ananda Labs, founded by @HebrewU 's Prof. Yossi Buganim, was featured in @ISRAEL21c for its groundbreaking research on reversing aging. Their epigenetic reprogramming tech targets age-related diseases, rejuvenates skin, and boosts immune health. www.israel21c.org/the-company-...

israel21c.org

Ananda Labs: Slowing down the aging process

Ananda Labs is developing novel solutions for aging-related conditions from wrinkles, to scars to a more youthful immune system through epigenetic editing.

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