Yao Chen @yaochen20.bsky.social · 09/07/2026After sleep deprivation, membrane PKA-SP reaches a lower level by the end of each bout, reflecting greater dissipation of accumulated sleep need. (7/10) 100
Yao Chen @yaochen20.bsky.social · 09/07/2026Importantly, membrane PKA-SP continuously tracks moment-to-moment waking probability. It achieves this by integrating both how long the animal has slept and how much sleep has been interrupted. (6/10) 100
Yao Chen @yaochen20.bsky.social · 09/07/2026These dynamics are specific to the membrane: PKA-SP inside the cell behaves differently. The same molecule in two subcellular compartments displays two distinct dynamics. (5/10) 110
Yao Chen @yaochen20.bsky.social · 09/07/2026Using optical biosensors in freely behaving mice, we found that protein kinase A substrate phosphorylation (PKA-SP) at the neuronal membrane decreases exponentially through each sleep bout, with consistent kinetics. (4/10) 100
Yao Chen @yaochen20.bsky.social · 09/07/2026How does the brain track how much sleep has occurred, and gauge the likelihood of waking at each moment? Check out our new preprint: “A molecular integrator of sleep duration and interruption” www.biorxiv.org/content/10.6... (1/10) 1236
Yao Chen @yaochen20.bsky.social · 09/07/2026After sleep deprivation, membrane PKA-SP reaches a lower level by the end of each bout, reflecting greater dissipation of accumulated sleep need. (7/10) 100
Yao Chen @yaochen20.bsky.social · 09/07/2026Importantly, membrane PKA-SP continuously tracks moment-to-moment waking probability. It achieves this by integrating both how long the animal has slept and how much sleep has been interrupted. (6/10) 100
Yao Chen @yaochen20.bsky.social · 09/07/2026These dynamics are specific to the membrane: PKA-SP inside the cell behaves differently. The same molecule in two subcellular compartments displays two distinct dynamics. (5/10) 110
Yao Chen @yaochen20.bsky.social · 09/07/2026Using optical biosensors in freely behaving mice, we found that protein kinase A substrate phosphorylation (PKA-SP) at the neuronal membrane decreases exponentially through each sleep bout, with consistent kinetics. (4/10) 100