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Yao Chen

@yaochen20.bsky.social
160 followers 225 following 28 posts

Neuroscientist at Washington University in Saint Louis. Lab web site: sites.wustl.edu/yaochenlab

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Yao Chen @yaochen20.bsky.social · 09/07/2026
After sleep deprivation, membrane PKA-SP reaches a lower level by the end of each bout, reflecting greater dissipation of accumulated sleep need. (7/10)
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Yao Chen @yaochen20.bsky.social · 09/07/2026
Importantly, membrane PKA-SP continuously tracks moment-to-moment waking probability. It achieves this by integrating both how long the animal has slept and how much sleep has been interrupted. (6/10)
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Yao Chen @yaochen20.bsky.social · 09/07/2026
These dynamics are specific to the membrane: PKA-SP inside the cell behaves differently. The same molecule in two subcellular compartments displays two distinct dynamics. (5/10)
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Yao Chen @yaochen20.bsky.social · 09/07/2026
Using optical biosensors in freely behaving mice, we found that protein kinase A substrate phosphorylation (PKA-SP) at the neuronal membrane decreases exponentially through each sleep bout, with consistent kinetics. (4/10)
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Yao Chen @yaochen20.bsky.social · 09/07/2026
How does the brain track how much sleep has occurred, and gauge the likelihood of waking at each moment? Check out our new preprint: “A molecular integrator of sleep duration and interruption” www.biorxiv.org/content/10.6... (1/10)
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Yao Chen @yaochen20.bsky.social · 09/07/2026
After sleep deprivation, membrane PKA-SP reaches a lower level by the end of each bout, reflecting greater dissipation of accumulated sleep need. (7/10)
100
Yao Chen @yaochen20.bsky.social · 09/07/2026
Importantly, membrane PKA-SP continuously tracks moment-to-moment waking probability. It achieves this by integrating both how long the animal has slept and how much sleep has been interrupted. (6/10)
100
Yao Chen @yaochen20.bsky.social · 09/07/2026
These dynamics are specific to the membrane: PKA-SP inside the cell behaves differently. The same molecule in two subcellular compartments displays two distinct dynamics. (5/10)
110
Yao Chen @yaochen20.bsky.social · 09/07/2026
Using optical biosensors in freely behaving mice, we found that protein kinase A substrate phosphorylation (PKA-SP) at the neuronal membrane decreases exponentially through each sleep bout, with consistent kinetics. (4/10)
100