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Yang Liu

@yangliu-lmb.bsky.social
8 followers 20 following 10 posts

Synthetic biologist @ MRC Laboratory of Molecular Biology, Cambridge. Building programmable biosystems for lab evolution, RNA technologies, and living biosensors. Co-founder of iDEC.

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Yang Liu @yangliu-lmb.bsky.social · 28/07/2026
When we talk with AI researchers, one question comes up most frequently: do you have datasets focused on mutations at key protein positions? Until now, building libraries for that usually meant a lot of DNA synthesis. We developed HGT-DGR as a faster and cheaper way to make them.
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Yang Liu @yangliu-lmb.bsky.social · 27/07/2026
Excited to share this work—we’ve been waiting a long time for it. Can DGRs become a practical platform for continuous evolution? Without HGT, mutant cells do not accumulate efficiently. We developed HGT-DGR to solve this problem. www.biorxiv.org/content/10.6...
biorxiv.org
Continuous target-specific mutagenesis and rapid gene evolution by diversity-generating retroelements in Escherichia coli
Sequence-programmable directed evolution systems have great potential to accelerate bioengineering. Diversity-generating retroelements (DGRs) are natural hypermutation systems widely distributed in pr...
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