Yang Liu @yangliu-lmb.bsky.social · 28/07/2026When we talk with AI researchers, one question comes up most frequently: do you have datasets focused on mutations at key protein positions? Until now, building libraries for that usually meant a lot of DNA synthesis. We developed HGT-DGR as a faster and cheaper way to make them. 164
Yang Liu @yangliu-lmb.bsky.social · 27/07/2026Excited to share this work—we’ve been waiting a long time for it. Can DGRs become a practical platform for continuous evolution? Without HGT, mutant cells do not accumulate efficiently. We developed HGT-DGR to solve this problem. www.biorxiv.org/content/10.6...biorxiv.orgContinuous target-specific mutagenesis and rapid gene evolution by diversity-generating retroelements in Escherichia coliSequence-programmable directed evolution systems have great potential to accelerate bioengineering. Diversity-generating retroelements (DGRs) are natural hypermutation systems widely distributed in pr... 121