Excited to share DeepCompARE + ISA - a lightweight deep learning model + efficient interpretation method, to uncover rules of TF cooperativity via genome-wide in silico motif ablations!
Preprint: www.biorxiv.org/content/10.1...
Github: github.com/anderssonlab...
biorxiv.org
Genome-wide rules of transcription factor cooperativity revealed through in silico binding site ablation
Transcription factor (TF) cooperativity plays a critical role in gene regulation. However, the underlying genomic rules remain unclear, calling for scalable methods to characterize the TF binding site...