I’m concerned about PJ.2.1 descendants especially with S:A475V (now observed) or with S:D420N or S:N487D (neither observed). The preprint www.biorxiv.org/content/10.6... from Yunlong Cao’s group noted all 3 mutations as potentials for PJ.2.1, and that group has a track record of good predictions.
biorxiv.org
Increased receptor binding capability of the SARS-CoV-2 saltational variant PJ.2.1
The recently identified SARS-CoV-2 saltational variant PJ.2.1, a highly mutated descendant of MC.10.1, has achieved rapid intercontinental spread since its detection in May 2026. Here, we show that PJ...