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Monte Winslow Lab @winslowlab.bsky.social · 25/09/2025

Epigenomic changes are critical non-mutational cancer drivers. Jackie Tang in our lab lead a project to generate a phenotypic roadmap of epigenomic regulators in lung tumorigenesis. Lots of unexpected and interesting tumor suppressors including the HBO1 complex doi.org/10.1158/2159-8290.CD-24-1565

doi.org

Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes

Abstract. Epigenomic dysregulation is widespread in cancer. However, the specific epigenomic regulators and the processes they control to drive cancer phenotypes are poorly understood. We employed a n...

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