iiinova — where your digital self keeps evolving

WIMI Biotech @wimi-bio-tech.bsky.social · 29/09/2026

Anhui Science and Technology University researchers established a seasonality-free mature embryo transformation engine in bread wheat, achieving up to 2.5% stable transformation and 37.8% #CRISPR/Cas9 editing efficiency at the Rht12 locus. 🌾🤖 #WheatGenomics #TissueCulture #MatureEmbryo

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WIMI Biotech @wimi-bio-tech.bsky.social · 28/09/2026

Traver Hart’s team evaluated a 77,000 dual-gRNA Cas12a library on bioRxiv, revealing that dual-target locus excision operates at very low efficiency in mammalian screens due to asynchronous cleavage dynamics. 🧬🤖 #CRISPR #Cas12a #bioRxiv2026 #MDAnderson #GeneEditing #FunctionalGenomics

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WIMI Biotech @wimi-bio-tech.bsky.social · 28/09/2026

NWAFU researchers developed PrePssmCas, a classifier fusing ESM1b language embeddings and evolutionary PSSM profiles to achieve 97.98% accuracy in distinguishing Cas from non-Cas proteins. 🧬🤖 #CRISPR #Bioinformatics #NWAFU #ProteinLanguageModels #CasDiscovery #AIinBiotech

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WIMI Biotech @wimi-bio-tech.bsky.social · 28/09/2026

#UCBerkeley researchers developed PERCEPT, using self-immolative reduction-sensitive linkers to decorate #CRISPR #RNPs with PEG, escape peptides, and targeting ligands for targeted in vivo editing across brain, retina, muscle, and lung tissues. 🧠🤖 #GeneEditing #bioRxiv2026 #PERCEPT #BaseEditing

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WIMI Biotech @wimi-bio-tech.bsky.social · 28/09/2026

#CAAS researchers combined k-mer GWAS and autotetraploid #CRISPR editing in #alfalfa to decode the #MsCBF8-MsGolS2 module, which coordinates dynamic stomatal closure, ROS scavenging, and raffinose synthesis for enhanced #drought survival with zero yield penalty. 🌿🤖 #ForageBreeding

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WIMI Biotech @wimi-bio-tech.bsky.social · 23/09/2026

Researchers discovered that the superior #wheat allele #TaNPF7.6-A1mod (V431A) sequesters repressor TaJAZ1 in the cytoplasm to unleash TF TaEIL3, driving a positive feedback loop that enhances tonoplast nitrate efflux, tillering, and grain yield without #protein dilution. 🌾🤖

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WIMI Biotech @wimi-bio-tech.bsky.social · 23/09/2026

Meng et al. developed #BPGA, an enzyme-free in vivo Bxb1-ParA recombinase system in standard DH5α E. coli that iteratively stacks #multi-gene plant vectors, demonstrated by assembling a 9-TU, 41.551 kb andrographolide pathway construct. 🌿🤖 #PlantPhysiology #SyntheticBiology #MetabolicEngineering

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WIMI Biotech @wimi-bio-tech.bsky.social · 23/09/2026

The UK's #ARIA has committed £54M to explore whether #geneediting, genomics, and AI can help wild species adapt faster than climate change, through 13 projects still confined to controlled research. aria.org.uk/opportunity-...

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WIMI Biotech @wimi-bio-tech.bsky.social · 23/09/2026

Shahid Mansoor’s team reviewed the evolution of plant #primeediting from PE1 to AI-designed PE8, highlighting pegRNA stabilization, cis-regulatory expression tuning, and PE-recombinase systems for predictive crop breeding. 🌾🤖 #PlantBiotech2026 #TrendsInPlantScience #CropGenomics #AIinBiotech

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WIMI Biotech @wimi-bio-tech.bsky.social · 22/09/2026

#WEHI researchers developed #Partita, a high-density mouse genome-wide #CRISPRa library (263,460 sgRNAs), mapping #cancer dependencies, Irx5-driven venetoclax resistance, and in vivo MYC-synergistic oncogenes (Runx2/Runx3/Csf1r). 🐭🤖 #ScienceAdvances2026 #DrugResistance #InVivoScreening

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WIMI Biotech @wimi-bio-tech.bsky.social · 22/09/2026

CAS researchers assembled a 568.88 Mb #T2T gapless genome of Medicago lupulina and established its first #CRISPR/Cas9 editing platform, targeting MlPINNA1 to generate a 5-leaflet pentafoliate mutant phenotype. 🌿🤖 #MedicagoLupulina #JIPB2026 #LegumeGenomics #ForageBreeding #AgBiotech

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WIMI Biotech @wimi-bio-tech.bsky.social · 21/09/2026

Huazhong Agricultural University researchers deployed transcript-specific #CRISPR editing to uncouple overlapping genes at the OsRLCK280/NAT1 locus, proving #OsRLCK280 governs blast #immunity and BR signaling while #antisense NAT1 independently regulates #grainlength. 🌾🤖 #RiceGenomics #KabinXie

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WIMI Biotech @wimi-bio-tech.bsky.social · 20/09/2026

Researchers demonstrated that deleting Domain-V from gymnosperm #PdeLAZY1 abolishes its upright-promoting activity but fails to complement poplar tac1 knockouts, disproving the single-step deletion hypothesis for #TAC1 evolution. 🌲🤖 #PlantGenomics #PoplarBiotech #PlantArchitecture #Forestry

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WIMI Biotech @wimi-bio-tech.bsky.social · 20/09/2026

#JenniferDoudna’s team discovered #VIPR, a pre-CRISPR viral #RNA-guided system that uses an ancestral RAMP protein and a noncontiguous "1-nt skip" pairing code (NN-x-NN) for PAM-free programmable gene repression. 🧬🤖 #Science2026 #CRISPR #UCBerkeley #GeneEditing

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WIMI Biotech @wimi-bio-tech.bsky.social · 20/09/2026

#PekingUniversity researchers discovered PmCas12m—a naturally nuclease-dead miniature Cas nuclease—and engineered #xCas12m (581 aa), enabling #single-AAV packaging of xCas12m-CRISPRoff for durable in vivo HBV epigenetic silencing in mice. 🧬🤖 #Epigenetics #CRISPRoff #GeneTherapy #HBV

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WIMI Biotech @wimi-bio-tech.bsky.social · 18/09/2026

The UK has approved its first precision-bred crop — a vitamin D–biofortified tomato from the #JohnInnesCentre delivering roughly the vitamin D of 2 eggs per fruit — while #WiMi supports #knockout, #baseediting, and #knock-in transformation across 30+ crop species and genetic backgrounds.

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WIMI Biotech @wimi-bio-tech.bsky.social · 18/09/2026

Researchers established a 17.5% efficient stable transformation platform in 'Taishan Red' #pomegranate, proving that the SG6 R2R3-MYB factor #PgMYB10 master-regulates #anthocyanin biosynthesis by co-activating six key structural genes to drive a 5.4-fold pigment surge. 🍎🤖 #WoodyFruit

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WIMI Biotech @wimi-bio-tech.bsky.social · 18/09/2026

Researchers cloned maize Miniature5 (Mn5), revealing that a natural missense variant in this P-type PPR protein impairs mitochondrial nad1 trans-splicing and complex I assembly to regulate kernel size without seed lethality. 🌽🤖 #MaizeGenomics #Mn5 #PPRprotein #Mitochondria #GrainYield #AgBiotech

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WIMI Biotech @wimi-bio-tech.bsky.social · 18/09/2026

Mohankumar et al. demonstrated that #truncatinggRNAs to 15–19 nt narrows the #baseediting window to suppress bystander mutations across ABE and CBE platforms, with 17 nt guides optimizing target precision during transient delivery in primary CD34+ HSPCs. 🩸🤖 #BystanderEditing #HSPCs #GeneTherapy

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WIMI Biotech @wimi-bio-tech.bsky.social · 17/09/2026

CAAS researchers used #CRISPR/Cas9 to knock out NtCYP94B3 in tobacco, preventing JA-Ile degradation to elevate trypsin inhibitor (+43.5%) and nicotine (+34.8%), suppressing Spodoptera litura cutworms without field yield drag. 🌿🤖 #TobaccoGenomics #PlantBiotech2026 #InsectResistance #Jasmonate

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WIMI Biotech @wimi-bio-tech.bsky.social · 17/09/2026

Researchers developed a season-independent callus induction pipeline for recalcitrant African tropical maize using seedling-derived split internodes, achieving up to 76.2% induction in the CHABA landrace without immature embryos. 🌽🤖 #MaizeGenomics #TropicalAgriculture #CropBiotech #TissueCulture

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WIMI Biotech @wimi-bio-tech.bsky.social · 16/09/2026

SUSTech researchers engineered Cas12i3 variant Cas-SF01 to achieve up to 90.2% editing efficiency at TTN PAMs in tomato, producing high-GABA fruits and matching Cas9 performance at multiple loci. 🍅🤖 #TomatoGenomics #Cas12i3 #JIPB2026 #CRISPR #PlantBiotech #GABA #SUSTech

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WIMI Biotech @wimi-bio-tech.bsky.social · 16/09/2026

#ZhengzhouUniversity researchers developed #DipTRANS, a tissue-culture-free in planta transformation engine using DR reprogramming, vegetative cuttings, and #TRV-Cre/VIGE to achieve 46.7% direct transformation and scarless transgene-free editing in Nicotiana benthamiana. 🌿🤖

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WIMI Biotech @wimi-bio-tech.bsky.social · 15/09/2026

Researchers established the first reproducible in vitro regeneration platform for the Chilean metallophyte grass #Polypogonaustralis, achieving a 45% regeneration efficiency directly on callus induction medium to unlock heavy metal #phytoremediation biotechnology. 🌾🤖 #MiningRestoration

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WIMI Biotech @wimi-bio-tech.bsky.social · 15/09/2026

Feng Zhang and Guilhem Faure’s teams discovered that naturally nuclease-inactive TIGR-Tas systems use dual-spacer tigRNAs to act as natural RNA-guided transcriptional repressors in E. coli. 🧬🤖 #FengZhang #TIGRTas #CRISPRi #bioRxiv2026 #SyntheticBiology #RNAguided #BroadInstitute

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WIMI Biotech @wimi-bio-tech.bsky.social · 15/09/2026

CAAS researchers developed ePPEplus-MsV2 to perform the first multi-gene prime editing in alfalfa, engineering MsALS1, MsALS2, and MsACC1 to create dual nicosulfuron and haloxyfop herbicide-resistant germplasm. 🌿🤖 #AlfalfaGenomics #PrimeEditing #PlantBiotechJournal2026 #HerbicideResistance

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WIMI Biotech @wimi-bio-tech.bsky.social · 14/09/2026

Fudan University researchers developed #etBE, an engineered Transformer #BaseEditor with up to 35-fold higher C-to-T editing efficiency that achieved 35.13% in vivo liver editing and a 33% LDL-C reduction in mice without off-target trade-offs. 🧬🤖 #FudanUniversity #GeneTherapy #PCSK9

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WIMI Biotech @wimi-bio-tech.bsky.social · 14/09/2026

#ColumbiaUniversity researchers demonstrated that ABE8e-V106W RNP achieves 100% on-target editing in human embryos without #Cas9 -like double-strand breaks, but uncontained off-target editing, bystander mutations, and mosaicism render clinical reproductive use premature. 🧬🤖 #HumanEmbryo #PCSK9

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WIMI Biotech @wimi-bio-tech.bsky.social · 14/09/2026

Shanghai Normal University researchers developed ePE-P3-SpRY, an optimized PAM-flexible prime editing system that overcomes SpRY activity loss in rice to achieve up to 96% precise editing across NAN, NGN, NCN, and NTN motifs. 🌾🤖 #RiceGenomics #PrimeEditing #SpRY #NewPhytologist #CropBiotech

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WIMI Biotech @wimi-bio-tech.bsky.social · 14/09/2026

IPK Gatersleben researchers established the first base editing platform in barley, targeting HvEIF4E to create novel BE alleles 7 & 8 that confer robust BaMMV resistance without sacrificing grain yield. 🌾🤖 #BarleyGenomics #BaseEditing #bioRxiv2026 #PlantBiotech #CropProtection #EIF4E

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WIMI Biotech @wimi-bio-tech.bsky.social · 11/09/2026

Sun Yat-sen University researchers established the first plant cell-based #CRISPRa screen, identifying #OsTV1—a papillae-specific receptor kinase that interacts with silicon transporter OsSIET4 to drive broad-spectrum fungal resistance in #rice without yield penalties. 🌾🤖

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WIMI Biotech @wimi-bio-tech.bsky.social · 11/09/2026

TU Munich researchers used RFdiffusion AI to create synthetic transfer vehicles (STV-C8) that outperform LNPs by >1,000-fold in RNA delivery and achieve in vivo CRISPR editing in pigs. 🧬🤖 #Nature2026 #RNADelivery #RFdiffusion #CRISPR #GeneTherapy #STVC8

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WIMI Biotech @wimi-bio-tech.bsky.social · 05/09/2026

Day 1 at #ICSPR2026 in Chengdu! 🇨🇳🌱 Excited to connect with plant scientists & showcase WiMi Biotech's upgraded maize & cereal crop transformation and CRISPR editing platforms. 🌽 At the congress? Let’s grab a coffee during the tea break to discuss your crop research! ☕🤝 #PlantScience #AgTech #CRISPR

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WIMI Biotech @wimi-bio-tech.bsky.social · 03/09/2026

#QiheBiotech researchers co-engineered #Bxb1 recognition sites (attB(V111)) and recombinase mutants (V76C/R2Q) to achieve up to 30% CAR gene integration in human cells and 24% stable herbicide-resistance gene insertion in elite rice. 🌾🤖 #Recombinase #GeneTherapy #CropBreeding #PrecisionAg

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WIMI Biotech @wimi-bio-tech.bsky.social · 01/09/2026

Researchers identified the soybean dioxygenase gene GmSW6 via a 1,702-germplasm GWAS, using CRISPR knockouts to boost 100-seed weight and protein content without decreasing total yield per plant. 🫛🤖 #SoybeanGenomics #CRISPR #JAR2026 #CropBreeding #GmSW6 #AgBiotech

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WIMI Biotech @wimi-bio-tech.bsky.social · 01/09/2026

Vietnam Academy of Science and Technology researchers successfully deployed the AI-designed OpenCRISPR-1 nuclease in dicot plants, achieving 49.55% editing in soybean hairy roots and 75% T0 editing efficiency in tobacco. 🌿🤖 #OpenCRISPR #PlantGenomics #SoybeanEditing #CRISPR #bioRxiv2026 #AgBiotech

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WIMI Biotech @wimi-bio-tech.bsky.social · 01/09/2026

Researchers engineered flexiAsCas12a and the circular RNA-guided one-sniCPE2 split prime editor, expanding Cas12a PAM access to NATN/NCCN/GTCN motifs and raising theoretical human pathogenic SNV coverage to 95.86%. 🧬🤖 #PrimeEditing #Cas12a #flexiAsCas12a #GenomeBiology2026 #GeneTherapy #CRISPR

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WIMI Biotech @wimi-bio-tech.bsky.social · 01/09/2026

UT Health San Antonio researchers engineered U-report, a CBE/AMBER biosensor that quantifies live-cell chromosomal UNG activity in real time, revealing that mitochondrial UNG1 actively participates in nuclear uracil repair. 🧬🤖 #DNArepair #Ureport #BaseEditing #GenomicStability #Epigenetics

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WIMI Biotech @wimi-bio-tech.bsky.social · 31/08/2026

Fudan University researchers developed #DoPE, a donor-complementary #primeediting system that pairs opegRNAs with 3′-overhang dsDNA donors to achieve seamless 108 bp to 12.5 kb DNA insertions and high-throughput in situ saturation mutagenesis without DSBs. 🧬🤖 #CRISPR

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WIMI Biotech @wimi-bio-tech.bsky.social · 31/08/2026

Cornell researchers developed a transferable genetic toolkit for nonmodel gut #Clostridia featuring metatranscriptome-mined promoters, inducible TetR switches, and #CRISPR-Cas knockouts to reversibly tune bacterial TMA/TMAO metabolites in vivo. 🧬🤖 #Microbiome#SyntheticBiology #GutHealth

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WIMI Biotech @wimi-bio-tech.bsky.social · 31/08/2026

Thünen Institute researchers established the first transient CRISPR/Cas12a editing platform in European beech (Fagus sylvatica), achieving up to 32.69% editing efficiency at the FsPDS locus using temperature-tolerant ttLbCas12a in protoplasts. 🌳🤖 #CRISPR #Cas12a #FagusSylvatica #WoodyPlants

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WIMI Biotech @wimi-bio-tech.bsky.social · 31/08/2026

Researchers engineered A&GBE and the QBMM hypermutator (dTAGBE+AID) to achieve concurrent, balanced four-base (A, T, G, C) mutagenesis across a ~100 bp window in mammalian cells. 🧬🤖 #BaseEditing #NatComms2026 #GenomeEditing #DirectedEvolution #Hypermutator #MAP2K1

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WIMI Biotech @wimi-bio-tech.bsky.social · 28/08/2026

UPenn researchers developed a pooled mammalian screening framework for AI-designed ubiquibodies, using FACS and NGS to identify functional peptide-guided degraders targeting beta-catenin, GFAP, EWS::FLI1, and endogenous GATA2. 🧬🤖 #ProteinDegradation #TPD#bioRxiv2026 #AIProteinDesign #Ubiquibody

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WIMI Biotech @wimi-bio-tech.bsky.social · 28/08/2026

Researchers engineered #Barley stripe mosaic virus (BSMV-BE) to deliver sgRNAs into stable CBE/ABE #wheat lines, achieving up to 87.7% somatic editing, 30.2% virus-free M1 heritable transmission, and nicosulfuron-resistant TaALS mutants without tissue culture. 🌾🤖 #BaseEditing #BSMV #CRISPR

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WIMI Biotech @wimi-bio-tech.bsky.social · 27/08/2026

Max Planck researchers established isotopic proof of an operational four-step C4 photosynthetic cycle in transgenic C3 rice, identifying intercellular substrate transport rather than enzyme capacity as the primary bottleneck. 🌾🤖 #C4Rice #Photosynthesis #bioRxiv #PlantBiotech #CropGenomics

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WIMI Biotech @wimi-bio-tech.bsky.social · 27/08/2026

Singh et al. established a direct-organogenesis pea CRISPR editing pipeline using de-capped nodal explants and an AtU6-26 dual-gRNA vector, achieving 8.85% stable transformation and up to 97% PsPDS knockout efficiency. 🫛🤖 #PlantGenomics #PisumSativum #CRISPR #PeaEditing #Agrobacterium#AgBiotech

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WIMI Biotech @wimi-bio-tech.bsky.social · 27/08/2026

Chung-Ang University researchers developed an ultra-compact ~1,173 bp #TnpB system that switches between transcriptional activation (10 nt guide) and gene editing (20 nt guide), achieving #single-AAV mouse liver Pcsk9 editing in NAR. 🧬🤖

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WIMI Biotech @wimi-bio-tech.bsky.social · 26/08/2026

Researchers established a multi-factorial optimization framework for peanut somatic embryogenesis—boosting low-responder varieties from <30% to >85% induction via C/N tuning—and identified the PLAT domain protein #ATS3B as a key regeneration driver. 🥜🤖

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WIMI Biotech @wimi-bio-tech.bsky.social · 26/08/2026

AstraZeneca and CRUK researchers engineered mascRNA-processed conditional sgRNAs that utilize endogenous RNase P/Z to strip 34 nt loxP scars, restoring rapid #Cas9 editing kinetics without OFF-state leakiness. 🧬🤖 #GeneEditing #bioRxiv #AstraZeneca #ConditionalCRISPR #CancerResearch #SyntheticBiology

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WIMI Biotech @wimi-bio-tech.bsky.social · 25/08/2026

Caixia Gao's team co-engineered the ultra-compact ISCro4 bridge recombinase and bRNA to achieve a 30-fold efficiency boost, single-AAV delivery, and seamless 315 kb promoter-swapping inversions in rice. 🌾🤖 #PlantGenomics #BridgeRNA #TrendsInBiotech2026 #CaixiaGao #GeneEditing #AgBiotech

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