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Willie Neiswanger

@willieneis.bsky.social
7.3K followers 190 following 235 posts

Assistant Professor in CS + AI at USC. Previously at Stanford, CMU. Machine Learning, Decision Making, AI-for-Science, Generative AI, ML Systems, LLMs. willieneis.github.io

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Ameya Godbole @ameyagodbole.bsky.social · 24/10/2025
Announcing 🔭Hubble, a suite of open-source LLMs to advance the study of memorization! Pretrained 1B/8B param models, with controlled insertion of texts designed to emulate key memorization risks: copyright (e.g., book passages), privacy (e.g., synthetic biographies), and test set contamination
Hubble Suite logo (cloth patch with names of key organizations involved: USC, MPI, NVIDIA)
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Shangshang Wang @shangshang-wang.bsky.social · 23/04/2025
😃 Want strong LLM reasoning without breaking the bank? We explored just how cost-effectively RL can enhance reasoning using LoRA! [1/9] Introducing Tina: A family of tiny reasoning models with strong performance at low cost, providing an accessible testbed for RL reasoning. 🧵
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Shangshang Wang @shangshang-wang.bsky.social · 19/02/2025
🔍 Diving deep into LLM reasoning? From OpenAI's o-series to DeepSeek R1, from post-training to test-time compute — we break it down into structured spreadsheets. 🧵
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Willie Neiswanger @willieneis.bsky.social · 12/02/2025
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Willie Neiswanger @willieneis.bsky.social · 07/01/2025
Our paper also contains an in-depth discussion on safety when releasing metagenomic models. Looking for collaborators to build on this with us — please reach out! metagene.ai
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Willie Neiswanger @willieneis.bsky.social · 07/01/2025
We leverage the ecosystem of modern LLM tooling—in tokenization, model architecture, training, infra, etc—for performance and extensibility. METAGENE-1 is standardized & easy to use. Hugging Face: huggingface.co/metagene-ai Github: github.com/metagene-ai
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Willie Neiswanger @willieneis.bsky.social · 07/01/2025
​​METAGENE-1 shows state-of-the-art results on pathogen detection, metagenomic embedding, and other genomic tasks. We also release new benchmarks for genomic detection and embedding (eg, Gene-MTEB, based on MTEB for LLMs). See our paper for details: arxiv.org/abs/2501.02045
A subset of results on our Genomic Embedding Benchmark and Pathogen Detection Benchmark.
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Willie Neiswanger @willieneis.bsky.social · 07/01/2025
Our data pipeline is: human microbiome > wastewater > metagenomic sequences > tokens > training data. Wastewater provides a rich source of data from tens of thousands of species across the human-adjacent microbiome. In total we pretrain on over 1.5T base pairs of DNA/RNA.
Overview of the metagenomic data collection and sequencing pipeline for model pretraining.
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Willie Neiswanger @willieneis.bsky.social · 07/01/2025
Metagenomic sequencing of wastewater produces vast amounts of data that can capture public health trends at a societal scale. Our goal is to train a model on this data to help in large-scale wastewater monitoring & detection of novel bio threats.
Overview of METAGENE-1 and applications.
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Willie Neiswanger @willieneis.bsky.social · 07/01/2025
Excited to release METAGENE-1, a 7B parameter metagenomic foundation model, built to aid in pathogen detection & pandemic monitoring. Pretrained on 1.5 trillion base pairs of DNA/RNA sequenced from wastewater. A collab w/ USC, PrimeIntellect, & the Nucleic Acid Observatory. metagene.ai
metagene.ai
Metagenomic Foundation Model
Metagenomic Foundation Model for Pandemic Monitoring
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Keenan Crane @keenancrane.bsky.social · 09/12/2024
Entropy is one of those formulas that many of us learn, swallow whole, and even use regularly without really understanding. (E.g., where does that “log” come from? Are there other possible formulas?) Yet there's an intuitive & almost inevitable way to arrive at this expression.
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Willie Neiswanger @willieneis.bsky.social · 07/12/2024
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Willie Neiswanger @willieneis.bsky.social · 06/12/2024
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Brandon Amos @bdamos.bsky.social · 05/12/2024
hi everyone!! let's try this optimal transport again 🙃
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Drew Berry wehi.tv @drewberry.bsky.social · 04/12/2024
Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs
youtu.be
DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv
YouTube video by WEHImovies
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Willie Neiswanger @willieneis.bsky.social · 03/12/2024
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Willie Neiswanger @willieneis.bsky.social · 02/12/2024
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Willie Neiswanger @willieneis.bsky.social · 02/12/2024
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Willie Neiswanger @willieneis.bsky.social · 02/12/2024
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Willie Neiswanger @willieneis.bsky.social · 01/12/2024
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Willie Neiswanger @willieneis.bsky.social · 30/11/2024
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Willie Neiswanger @willieneis.bsky.social · 28/11/2024
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Willie Neiswanger @willieneis.bsky.social · 28/11/2024
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Willie Neiswanger @willieneis.bsky.social · 28/11/2024
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Reposted by Willie Neiswanger
Mathurin Massias @mathurinmassias.bsky.social · 27/11/2024
Anne Gagneux, Ségolène Martin, @quentinbertrand.bsky.social Remi Emonet and I wrote a tutorial blog post on flow matching: dl.heeere.com/conditional-... with lots of illustrations and intuition! We got this idea after their cool work on improving Plug and Play with FM: arxiv.org/abs/2410.02423
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Willie Neiswanger @willieneis.bsky.social · 27/11/2024
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Willie Neiswanger @willieneis.bsky.social · 26/11/2024
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Willie Neiswanger @willieneis.bsky.social · 26/11/2024
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Willie Neiswanger @willieneis.bsky.social · 26/11/2024
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Willie Neiswanger @willieneis.bsky.social · 26/11/2024
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Willie Neiswanger @willieneis.bsky.social · 26/11/2024
Can I join?
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Willie Neiswanger @willieneis.bsky.social · 26/11/2024
Can I join?
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Willie Neiswanger @willieneis.bsky.social · 25/11/2024
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Willie Neiswanger @willieneis.bsky.social · 25/11/2024
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Willie Neiswanger @willieneis.bsky.social · 24/11/2024
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Willie Neiswanger @willieneis.bsky.social · 24/11/2024
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Willie Neiswanger @willieneis.bsky.social · 24/11/2024
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